Electrochemical Characterization and Voltammetric Determination of Benzoyl Derivatives of Phenobarbital Using Glassy Carbon Electrode

Olga Mezentseva, Galina Slepchenko, Victor Filimonov, Elena Mikheeva, Galina Arbit

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The electrochemical behavior of a number of benzoyl barbiturates was studied using a glassy carbon electrode (GCE). The kinetics of the electrode process is determined, the contribution of physical adsorption to the electrochemical process is estimated, and the mechanism of the possible electrochemical reaction is proposed. It is shown that the electrochemical reduction potentials of benzoyl phenobarbital derivatives are determined by the LUMO energies, calculated by the B3LYP 6-311+G method. It is established that the process is quasi-reversible, complicated by adverse reactions. The influence of halogen type and its position in the benzoyl residue of the studied substances on the analytical signal is established. The effective values of the dissociation constants of various forms of benzoyl derivatives were calculated using the example of halonal, for which the values 3.16 ⋅ 10−8 and 6.31 ⋅ 10−12, respectively, were found.

Original languageEnglish
Pages (from-to)1494-1500
Number of pages7
Issue number8
Publication statusPublished - 1 Jan 2019



  • Benzoyl derivatives of barbituric acid
  • differential pulse voltammetry
  • glassy carbon electrode
  • mechanism of electrochemical reaction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

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