Electrochemical Characterization and Voltammetric Determination of Benzoyl Derivatives of Phenobarbital Using Glassy Carbon Electrode

Olga Mezentseva, Galina Slepchenko, Victor Filimonov, Elena Mikheeva, Galina Arbit

Research output: Contribution to journalArticle

Abstract

The electrochemical behavior of a number of benzoyl barbiturates was studied using a glassy carbon electrode (GCE). The kinetics of the electrode process is determined, the contribution of physical adsorption to the electrochemical process is estimated, and the mechanism of the possible electrochemical reaction is proposed. It is shown that the electrochemical reduction potentials of benzoyl phenobarbital derivatives are determined by the LUMO energies, calculated by the B3LYP 6-311+G method. It is established that the process is quasi-reversible, complicated by adverse reactions. The influence of halogen type and its position in the benzoyl residue of the studied substances on the analytical signal is established. The effective values of the dissociation constants of various forms of benzoyl derivatives were calculated using the example of halonal, for which the values 3.16 ⋅ 10−8 and 6.31 ⋅ 10−12, respectively, were found.

Original languageEnglish
Pages (from-to)1494-1500
Number of pages7
JournalElectroanalysis
Volume31
Issue number8
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Glassy carbon
Phenobarbital
Derivatives
Electrodes
Barbiturates
Halogens
Adsorption
Kinetics
halonal

Keywords

  • Benzoyl derivatives of barbituric acid
  • differential pulse voltammetry
  • glassy carbon electrode
  • mechanism of electrochemical reaction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

Cite this

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abstract = "The electrochemical behavior of a number of benzoyl barbiturates was studied using a glassy carbon electrode (GCE). The kinetics of the electrode process is determined, the contribution of physical adsorption to the electrochemical process is estimated, and the mechanism of the possible electrochemical reaction is proposed. It is shown that the electrochemical reduction potentials of benzoyl phenobarbital derivatives are determined by the LUMO energies, calculated by the B3LYP 6-311+G method. It is established that the process is quasi-reversible, complicated by adverse reactions. The influence of halogen type and its position in the benzoyl residue of the studied substances on the analytical signal is established. The effective values of the dissociation constants of various forms of benzoyl derivatives were calculated using the example of halonal, for which the values 3.16 ⋅ 10−8 and 6.31 ⋅ 10−12, respectively, were found.",
keywords = "Benzoyl derivatives of barbituric acid, differential pulse voltammetry, glassy carbon electrode, mechanism of electrochemical reaction",
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T1 - Electrochemical Characterization and Voltammetric Determination of Benzoyl Derivatives of Phenobarbital Using Glassy Carbon Electrode

AU - Mezentseva, Olga

AU - Slepchenko, Galina

AU - Filimonov, Victor

AU - Mikheeva, Elena

AU - Arbit, Galina

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The electrochemical behavior of a number of benzoyl barbiturates was studied using a glassy carbon electrode (GCE). The kinetics of the electrode process is determined, the contribution of physical adsorption to the electrochemical process is estimated, and the mechanism of the possible electrochemical reaction is proposed. It is shown that the electrochemical reduction potentials of benzoyl phenobarbital derivatives are determined by the LUMO energies, calculated by the B3LYP 6-311+G method. It is established that the process is quasi-reversible, complicated by adverse reactions. The influence of halogen type and its position in the benzoyl residue of the studied substances on the analytical signal is established. The effective values of the dissociation constants of various forms of benzoyl derivatives were calculated using the example of halonal, for which the values 3.16 ⋅ 10−8 and 6.31 ⋅ 10−12, respectively, were found.

AB - The electrochemical behavior of a number of benzoyl barbiturates was studied using a glassy carbon electrode (GCE). The kinetics of the electrode process is determined, the contribution of physical adsorption to the electrochemical process is estimated, and the mechanism of the possible electrochemical reaction is proposed. It is shown that the electrochemical reduction potentials of benzoyl phenobarbital derivatives are determined by the LUMO energies, calculated by the B3LYP 6-311+G method. It is established that the process is quasi-reversible, complicated by adverse reactions. The influence of halogen type and its position in the benzoyl residue of the studied substances on the analytical signal is established. The effective values of the dissociation constants of various forms of benzoyl derivatives were calculated using the example of halonal, for which the values 3.16 ⋅ 10−8 and 6.31 ⋅ 10−12, respectively, were found.

KW - Benzoyl derivatives of barbituric acid

KW - differential pulse voltammetry

KW - glassy carbon electrode

KW - mechanism of electrochemical reaction

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