Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.
- Enzyme-inducing agents
- Intrahepatic cholestasis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)