Abstract
Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.
| Original language | English |
|---|---|
| Pages (from-to) | 271-273 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 134 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Sep 2002 |
Keywords
- Enzyme-inducing agents
- Intrahepatic cholestasis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Fingerprint Dive into the research topics of 'Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis'. Together they form a unique fingerprint.
Cite this
Saratikov, A. S., Novozheeva, T. P., & Akhmedzhanov, R. R. (2002). Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis. Bulletin of Experimental Biology and Medicine, 134(3), 271-273. https://doi.org/10.1023/A:1021563703378