Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis

Abstract

Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.

Original language	English
Pages (from-to)	271-273
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	134
Issue number	3
DOIs	https://doi.org/10.1023/A:1021563703378
Publication status	Published - 1 Sep 2002

Keywords

Enzyme-inducing agents
Intrahepatic cholestasis

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis",

abstract = "Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.",

keywords = "Enzyme-inducing agents, Intrahepatic cholestasis",

author = "Saratikov, {Albert S.} and Novozheeva, {T. P.} and Akhmedzhanov, {R. R.}",

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AU - Saratikov, Albert S.

AU - Novozheeva, T. P.

AU - Akhmedzhanov, R. R.

PY - 2002/9/1

Y1 - 2002/9/1

N2 - Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.

AB - Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.

KW - Enzyme-inducing agents

KW - Intrahepatic cholestasis

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