Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis

Albert S. Saratikov, T. P. Novozheeva, R. R. Akhmedzhanov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume134
Issue number3
DOIs
Publication statusPublished - 1 Sep 2002

Fingerprint

Intrahepatic Cholestasis
Liver
Rats
Enzymes
Phenobarbital
Mixed Function Oxygenases
Bilirubin
Metabolism
Cytochrome P-450 Enzyme System
Hepatocytes
Substrates
Serum
Proteins
halonal
halodif

Keywords

  • Enzyme-inducing agents
  • Intrahepatic cholestasis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis. / Saratikov, Albert S.; Novozheeva, T. P.; Akhmedzhanov, R. R.

In: Bulletin of Experimental Biology and Medicine, Vol. 134, No. 3, 01.09.2002, p. 271-273.

Research output: Contribution to journalArticle

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