Abstract
Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.
| Original language | English |
|---|---|
| Pages (from-to) | 271-273 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 134 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Sep 2002 |
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Keywords
- Enzyme-inducing agents
- Intrahepatic cholestasis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis. / Saratikov, Albert S.; Novozheeva, T. P.; Akhmedzhanov, R. R.
In: Bulletin of Experimental Biology and Medicine, Vol. 134, No. 3, 01.09.2002, p. 271-273.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis
AU - Saratikov, Albert S.
AU - Novozheeva, T. P.
AU - Akhmedzhanov, R. R.
PY - 2002/9/1
Y1 - 2002/9/1
N2 - Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.
AB - Inductors of the monooxygenase system benzomal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by αnaphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.
KW - Enzyme-inducing agents
KW - Intrahepatic cholestasis
UR - http://www.scopus.com/inward/record.url?scp=0036770415&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036770415&partnerID=8YFLogxK
U2 - 10.1023/A:1021563703378
DO - 10.1023/A:1021563703378
M3 - Article
C2 - 12512000
AN - SCOPUS:0036770415
VL - 134
SP - 271
EP - 273
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 3
ER -