Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes

Peng Wu, Alina K. Feldman, Anne K. Nugent, Craig J. Hawker, Arnulf Scheel, Brigitte Voit, Jeffrey Pyun, Jean M J Fréchet, K. Barry Sharpless, Valery V. Fokin

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1077 Citations (Scopus)

Abstract

Components that click: A large number of diverse dendrimers (see scheme) was prepared in almost quantitative yield by the click-chemistry transformation described in the title. In some cases filtration or solvent extraction was the only method required for purification in this highly efficient construction of the triazole units of the dendrimers.

Original languageEnglish
Pages (from-to)3928-3932
Number of pages5
JournalAngewandte Chemie - International Edition
Volume43
Issue number30
DOIs
Publication statusPublished - 26 Jul 2004
Externally publishedYes

Keywords

  • Alkynes
  • Azides
  • Click chemistry
  • Copper
  • Dendrimers

ASJC Scopus subject areas

  • Chemistry(all)

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    Wu, P., Feldman, A. K., Nugent, A. K., Hawker, C. J., Scheel, A., Voit, B., Pyun, J., Fréchet, J. M. J., Sharpless, K. B., & Fokin, V. V. (2004). Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes. Angewandte Chemie - International Edition, 43(30), 3928-3932. https://doi.org/10.1002/anie.200454078