Effects of Tussilago farfara L. Polysaccharides on the Expression of PD-1 (CD279) and PD-L1 (CD274) in Peripheral Blood and Tumor Tissue Lymphocytes in Mice with Lewis Lung Carcinoma

E. A. Safonova, K. A. Lopatina, T. G. Razina, E. P. Zueva, A. M. Gur’ev, M. V. Belousov

Research output: Contribution to journalArticle

Abstract

One of prospective methods for immunotherapy of tumors is modulation via immunological checkpoints, specifically, via the PD-1(CD279)/PD-L1(CD274) system. Interactions between tumor cell receptor (CD279) and the ligand on lymphocytes (CD274) leads to lymphocyte inactivation, which allows tumor escape from the immune control. Experiments on C57BL/6 mice with Lewis lung carcinoma demonstrate the possibility of reducing the expression of CD279 and CD274 on the peripheral blood and tumor tissue lymphocytes under the effects of Tussilago farfara L. polysaccharides. This phenomenon can underlie the antitumor and antimetastatic effects of these substances.

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume169
Issue number3
DOIs
Publication statusPublished - 1 Jul 2020
Externally publishedYes

Keywords

  • flow cytofluorometry
  • immunotherapy
  • PD-1
  • PD-L1
  • polysaccharides

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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