Effects of strabismus and monocular deprivation on the sizes of callosal cells in cortical fields 17 and 18 in the cat brain

S. V. Alekseenko, P. Yu Shkorbatova, S. N. Toporova

Research output: Contribution to journalArticle

Abstract

Structural changes in the visual cortex were studied in conditions of deranged binocular experience by assessing the sizes (body areas) of callosal cells in fields 17 and 18 in monocularly deprived cats and in cats with convergent strabismus. These cells were detected by injection of horseradish peroxidase into columns in cortical fields 17 and 18 and the fields 17/18 transitional zone. In both groups, the mean size of callosal cells in field 17 was greater than normal, though this difference in field 18 was seen only in monocularly deprived cats. Differences in the mean sizes of field 17 and 18 cells in cats of the study groups were found to be due to the number of large cells. In cats with strabismus, callosal cells of size greater than 200 μm2 accounted for 58% of cells in field 17 and 8% in field 18. In monocularly deprived cats, there was no difference in the proportions of large callosal cells in these fields (28% and 26%, respectively). These data provide evidence that cytoarchitectonic changes occurred in layers of the visual cortex, serving as sources of interhemisphere connections, in conditions of early derangement of binocular experience.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalNeuroscience and Behavioral Physiology
Volume44
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Keywords

  • callosal cell size
  • cat
  • monocular deprivation
  • strabismus
  • visual cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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