Effects of plant water-soluble polysaccharides on the production of immunoglobulins E and G1 by lymphocytes of mice sensitized with ovalbumin

M. G. Danilets, Nataly V. Belska, Y. P. Bel'sky, E. G. Uchasova, E. S. Trophimova, A. A. Ligatcheva, A. M. Guriev, M. V. Belousov, R. R. Ahmedganov, M. S. Usubov, V. I. Agaphonov

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Abstract

Were studied the effects of water-soluble plant polysaccharides isolated from pharmacopoeic raw material on anaphylactic shock and production of IgE and IgG1 by lymphocytes from mice immunized with ovalbumin. Course treatment with polysaccharides from coltsfoot, sweet flag, clover, Artemisia, marigold, and elecampane reduced animal mortality after induction of anaphylactic shock. In addition, injection of these substances reduced serum concentrations of IgE and IgG1. These substances can be regarded as promising agents for the treatment of IgE-dependent diseases (atopic dermatitis, asthma, atopic rhinitis, urticaria, food allergies, etc.).

Original languageEnglish
Pages (from-to)585-587
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume146
Issue number5
DOIs
Publication statusPublished - 1 Dec 2008

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Keywords

  • Anaphylactic shock
  • Atopy
  • Immunoglobulins E and G1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Danilets, M. G., Belska, N. V., Bel'sky, Y. P., Uchasova, E. G., Trophimova, E. S., Ligatcheva, A. A., Guriev, A. M., Belousov, M. V., Ahmedganov, R. R., Usubov, M. S., & Agaphonov, V. I. (2008). Effects of plant water-soluble polysaccharides on the production of immunoglobulins E and G1 by lymphocytes of mice sensitized with ovalbumin. Bulletin of Experimental Biology and Medicine, 146(5), 585-587. https://doi.org/10.1007/s10517-009-0351-3