Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development

Mark B. Plotnikov, Oleg I. Aliev, Alexander Y. Shamanaev, Anastasia V. Sidekhmenova, Yana Anfinogenova, Anna M. Anishchenko, Tatiana I. Fomina, Alexander M. Arkhipov

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The most common form of hypertension in young adults is isolated diastolic hypertension. Diastolic arterial pressure is determined by the total peripheral resistance and depends on both vascular hindrance and blood viscosity. The aim of our work was to study the efficiency of pentoxifylline (PTX) in young spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. The effects of a treatment course with PTX (100 mg/kg/day p.o. for 6 weeks, from 5 to 11 weeks old) on the mean, systolic, and diastolic blood pressure (BP); stroke volume; cardiac output; total peripheral resistance (TPR); whole blood viscosity (BV); plasma viscosity; hematocrit; RBC aggregation and deformability; local cerebral blood flow (lCBF); and microvascularization of the visual cortex were studied in SHRs in comparison with control SHRs and Wistar Kyoto rats. PTX-treated SHRs had significantly lower systolic, diastolic, and mean BP (by 24%, 26%, and 15%, respectively) and BV (by 5–9%) and a higher erythrocyte deformability index (by 1.5–2%), lCBF (by 42%), average diameter of capillaries (by 11%), density of the capillary network (by 23%), and percentage of capillaries with a diameter of 3–7 µm in comparison with control SHRs. In conclusion, PTX exerted positive effects on the hemodynamic, hemorheological, and microcirculatory parameters in SHRs during the development of arterial hypertension.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalClinical and Experimental Hypertension
Volume39
Issue number6
DOIs
Publication statusAccepted/In press - 19 Jul 2017

Fingerprint

Pentoxifylline
Inbred SHR Rats
Hemodynamics
Hypertension
Blood Viscosity
Cerebrovascular Circulation
Blood Pressure
Vascular Resistance
Erythrocyte Deformability
Erythrocyte Indices
Inbred WKY Rats
Visual Cortex
Hematocrit
Viscosity
Cardiac Output
Stroke Volume
Blood Vessels
Young Adult
Arterial Pressure

Keywords

  • Arterial blood pressure
  • blood viscosity
  • microcirculation in visual cortex
  • pentoxifylline
  • young SHRs

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development. / Plotnikov, Mark B.; Aliev, Oleg I.; Shamanaev, Alexander Y.; Sidekhmenova, Anastasia V.; Anfinogenova, Yana; Anishchenko, Anna M.; Fomina, Tatiana I.; Arkhipov, Alexander M.

In: Clinical and Experimental Hypertension, Vol. 39, No. 6, 19.07.2017, p. 1-9.

Research output: Contribution to journalArticle

Plotnikov, Mark B. ; Aliev, Oleg I. ; Shamanaev, Alexander Y. ; Sidekhmenova, Anastasia V. ; Anfinogenova, Yana ; Anishchenko, Anna M. ; Fomina, Tatiana I. ; Arkhipov, Alexander M. / Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development. In: Clinical and Experimental Hypertension. 2017 ; Vol. 39, No. 6. pp. 1-9.
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AU - Aliev, Oleg I.

AU - Shamanaev, Alexander Y.

AU - Sidekhmenova, Anastasia V.

AU - Anfinogenova, Yana

AU - Anishchenko, Anna M.

AU - Fomina, Tatiana I.

AU - Arkhipov, Alexander M.

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AB - The most common form of hypertension in young adults is isolated diastolic hypertension. Diastolic arterial pressure is determined by the total peripheral resistance and depends on both vascular hindrance and blood viscosity. The aim of our work was to study the efficiency of pentoxifylline (PTX) in young spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. The effects of a treatment course with PTX (100 mg/kg/day p.o. for 6 weeks, from 5 to 11 weeks old) on the mean, systolic, and diastolic blood pressure (BP); stroke volume; cardiac output; total peripheral resistance (TPR); whole blood viscosity (BV); plasma viscosity; hematocrit; RBC aggregation and deformability; local cerebral blood flow (lCBF); and microvascularization of the visual cortex were studied in SHRs in comparison with control SHRs and Wistar Kyoto rats. PTX-treated SHRs had significantly lower systolic, diastolic, and mean BP (by 24%, 26%, and 15%, respectively) and BV (by 5–9%) and a higher erythrocyte deformability index (by 1.5–2%), lCBF (by 42%), average diameter of capillaries (by 11%), density of the capillary network (by 23%), and percentage of capillaries with a diameter of 3–7 µm in comparison with control SHRs. In conclusion, PTX exerted positive effects on the hemodynamic, hemorheological, and microcirculatory parameters in SHRs during the development of arterial hypertension.

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