Effects of estradiol on lipoprotein lipase activity and lipid availability in exercised male rats

G. S. Ellis, S. Lanza-Jacoby, A. Gow, Z. V. Kendrick

    Research output: Contribution to journalArticle

    80 Citations (Scopus)

    Abstract

    The effects of 17β-estradiol 3-benzoate (10 μg · 0.1 ml sunflower oil- 1 · 100 g body wt-1) and exercise on tissue lipid content and lipoprotein lipase (LPL) activity were determined in male rats. Estradiol administration significantly (P <0.05) increased fatty acid contents of resting adipose, plasma, and white and red vastus muscle tissues and red vastus muscle triacylglycerol. Adipose and plasma fatty acids and red and white vastus muscle triacylglycerol were significantly higher in exercised estradiol- administered animals than in exercised oil-administered animals. Estradiol administration significantly reduced resting adipocyte LPL activity by 71% and increased myocardial LPL activity by 96%. After exercise, red vastus LPL activity was significantly increased by 76% in estradiol-administered animals compared with oil-administered animals. Ratios of red vastus to adipose LPL activity and myocardial to adipose LPL activity at rest and after exercise were significantly greater in estradiol-administered than in oil-administered animals. Estradiol administration significantly increased the ratio of white vastus to adipose LPL activity of exercised animals. These data indicate that estradiol increases the availability of lipid substrate to exercising muscle from multiple sources, including adipose, plasma, and intracellular muscle triacylglycerol. The absolute increases in muscle LPL activity, combined with a greater ratio of muscle to adipose LPL activity, lead to increased distribution of plasma triacylglycerol-derived fatty acids toward muscle.

    Original languageEnglish
    Pages (from-to)209-215
    Number of pages7
    JournalJournal of Applied Physiology
    Volume77
    Issue number1
    DOIs
    Publication statusPublished - 1994

    Fingerprint

    Lipoprotein Lipase
    Estradiol
    Lipids
    Muscles
    Triglycerides
    Oils
    Fatty Acids
    lissamine rhodamine B
    Adipocytes

    Keywords

    • adipose tissue
    • heart
    • skeletal muscle
    • submaximal exercise

    ASJC Scopus subject areas

    • Endocrinology
    • Physiology
    • Orthopedics and Sports Medicine
    • Physical Therapy, Sports Therapy and Rehabilitation

    Cite this

    Effects of estradiol on lipoprotein lipase activity and lipid availability in exercised male rats. / Ellis, G. S.; Lanza-Jacoby, S.; Gow, A.; Kendrick, Z. V.

    In: Journal of Applied Physiology, Vol. 77, No. 1, 1994, p. 209-215.

    Research output: Contribution to journalArticle

    Ellis, G. S. ; Lanza-Jacoby, S. ; Gow, A. ; Kendrick, Z. V. / Effects of estradiol on lipoprotein lipase activity and lipid availability in exercised male rats. In: Journal of Applied Physiology. 1994 ; Vol. 77, No. 1. pp. 209-215.
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