Abstract
Selective μ-opioid receptor agonist DAGO increased tolerance of isolated perfused rat heart to total ischemia (45 min) and reperfusion (60 min). Intravenous administration of DAGO (0,1 mg/kg) before of the heart isolation or direct pertusion by a solution containing DAGO (1 mg/l) prior of ischemia induction prevented reperfusion arrhythmias and subpression of cardiac contractility but had no effect on magnitude of contracture. Selective δ-opioid receptor agonist DSLET did not affect arrhythmias and cardiac contractility during postischemic period.
| Original language | English |
|---|---|
| Pages (from-to) | 25-30 |
| Number of pages | 6 |
| Journal | Kardiologiya |
| Volume | 38 |
| Issue number | 12 |
| Publication status | Published - 1998 |
Fingerprint
Keywords
- Heart, isolated
- Myocardial ischemia, reperfusion
- Receptors, opioid
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Effects of μ- and δ-opioid receptors ligands on rhythm and contractility disorders of isolated rat heart in postischemic period. / Maslov, L. N.; Lishmanov, Yu B.
In: Kardiologiya, Vol. 38, No. 12, 1998, p. 25-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of μ- and δ-opioid receptors ligands on rhythm and contractility disorders of isolated rat heart in postischemic period
AU - Maslov, L. N.
AU - Lishmanov, Yu B.
PY - 1998
Y1 - 1998
N2 - Selective μ-opioid receptor agonist DAGO increased tolerance of isolated perfused rat heart to total ischemia (45 min) and reperfusion (60 min). Intravenous administration of DAGO (0,1 mg/kg) before of the heart isolation or direct pertusion by a solution containing DAGO (1 mg/l) prior of ischemia induction prevented reperfusion arrhythmias and subpression of cardiac contractility but had no effect on magnitude of contracture. Selective δ-opioid receptor agonist DSLET did not affect arrhythmias and cardiac contractility during postischemic period.
AB - Selective μ-opioid receptor agonist DAGO increased tolerance of isolated perfused rat heart to total ischemia (45 min) and reperfusion (60 min). Intravenous administration of DAGO (0,1 mg/kg) before of the heart isolation or direct pertusion by a solution containing DAGO (1 mg/l) prior of ischemia induction prevented reperfusion arrhythmias and subpression of cardiac contractility but had no effect on magnitude of contracture. Selective δ-opioid receptor agonist DSLET did not affect arrhythmias and cardiac contractility during postischemic period.
KW - Heart, isolated
KW - Myocardial ischemia, reperfusion
KW - Receptors, opioid
UR - http://www.scopus.com/inward/record.url?scp=3643108828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3643108828&partnerID=8YFLogxK
M3 - Article
VL - 38
SP - 25
EP - 30
JO - Kardiologiya
JF - Kardiologiya
SN - 0022-9040
IS - 12
ER -