Abstract
Selective μ-opioid receptor agonist DAGO increased tolerance of isolated perfused rat heart to total ischemia (45 min) and reperfusion (60 min). Intravenous administration of DAGO (0,1 mg/kg) before of the heart isolation or direct pertusion by a solution containing DAGO (1 mg/l) prior of ischemia induction prevented reperfusion arrhythmias and subpression of cardiac contractility but had no effect on magnitude of contracture. Selective δ-opioid receptor agonist DSLET did not affect arrhythmias and cardiac contractility during postischemic period.
| Original language | English |
|---|---|
| Pages (from-to) | 25-30 |
| Number of pages | 6 |
| Journal | Kardiologiya |
| Volume | 38 |
| Issue number | 12 |
| Publication status | Published - 1998 |
Keywords
- Heart, isolated
- Myocardial ischemia, reperfusion
- Receptors, opioid
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Maslov, L. N., & Lishmanov, Y. B. (1998). Effects of μ- and δ-opioid receptors ligands on rhythm and contractility disorders of isolated rat heart in postischemic period. Kardiologiya, 38(12), 25-30.