Selective μ-opioid receptor agonist DAGO increased tolerance of isolated perfused rat heart to total ischemia (45 min) and reperfusion (60 min). Intravenous administration of DAGO (0,1 mg/kg) before of the heart isolation or direct pertusion by a solution containing DAGO (1 mg/l) prior of ischemia induction prevented reperfusion arrhythmias and subpression of cardiac contractility but had no effect on magnitude of contracture. Selective δ-opioid receptor agonist DSLET did not affect arrhythmias and cardiac contractility during postischemic period.
|Number of pages||6|
|Publication status||Published - 1998|
- Heart, isolated
- Myocardial ischemia, reperfusion
- Receptors, opioid
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine