Abstract
Selective μ-opioid receptor agonist DAGO increased tolerance of isolated perfused rat heart to total ischemia (45 min) and reperfusion (60 min). Intravenous administration of DAGO (0,1 mg/kg) before of the heart isolation or direct pertusion by a solution containing DAGO (1 mg/l) prior of ischemia induction prevented reperfusion arrhythmias and subpression of cardiac contractility but had no effect on magnitude of contracture. Selective δ-opioid receptor agonist DSLET did not affect arrhythmias and cardiac contractility during postischemic period.
Original language | English |
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Pages (from-to) | 25-30 |
Number of pages | 6 |
Journal | Kardiologiya |
Volume | 38 |
Issue number | 12 |
Publication status | Published - 1998 |
Keywords
- Heart, isolated
- Myocardial ischemia, reperfusion
- Receptors, opioid
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine