Effects of μ- and δ-opioid receptors ligands on rhythm and contractility disorders of isolated rat heart in postischemic period

L. N. Maslov, Yu B. Lishmanov

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Selective μ-opioid receptor agonist DAGO increased tolerance of isolated perfused rat heart to total ischemia (45 min) and reperfusion (60 min). Intravenous administration of DAGO (0,1 mg/kg) before of the heart isolation or direct pertusion by a solution containing DAGO (1 mg/l) prior of ischemia induction prevented reperfusion arrhythmias and subpression of cardiac contractility but had no effect on magnitude of contracture. Selective δ-opioid receptor agonist DSLET did not affect arrhythmias and cardiac contractility during postischemic period.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalKardiologiya
Volume38
Issue number12
Publication statusPublished - 1998

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Keywords

  • Heart, isolated
  • Myocardial ischemia, reperfusion
  • Receptors, opioid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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