Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117+34+) in the Bone Marrow of Mice Treated with Cyclophosphamide

Abstract

Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfara L. polysaccharides to C57BL/6 mice treated with cyclophosphamide can increase the number of hematopoietic stem cells (CD117⁺34⁺) in the bone marrow.

Original language	English
Pages (from-to)	171-174
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	170
Issue number	1
DOIs	https://doi.org/10.1007/s10517-020-05025-y
Publication status	Published - Nov 2020

Keywords

CD117
CD34
cyclophosphamide
flow cytometry
polysaccharides

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/s10517-020-05025-y

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Safonova, E. A., Lopatina, K. A., Dyagel, A. R., Razina, T. G., Krylova, S. G., Gur’ev, A. M., Belousov, M. V., & Zueva, E. P. (2020). Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117⁺34⁺) in the Bone Marrow of Mice Treated with Cyclophosphamide. Bulletin of Experimental Biology and Medicine, 170(1), 171-174. https://doi.org/10.1007/s10517-020-05025-y

Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117⁺34⁺) in the Bone Marrow of Mice Treated with Cyclophosphamide. / Safonova, E. A.; Lopatina, K. A.; Dyagel, A. R.; Razina, T. G.; Krylova, S. G.; Gur’ev, A. M.; Belousov, M. V.; Zueva, E. P.

In: Bulletin of Experimental Biology and Medicine, Vol. 170, No. 1, 11.2020, p. 171-174.

Research output: Contribution to journal › Article › peer-review

Safonova, EA, Lopatina, KA, Dyagel, AR, Razina, TG, Krylova, SG, Gur’ev, AM, Belousov, MV & Zueva, EP 2020, 'Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117⁺34⁺) in the Bone Marrow of Mice Treated with Cyclophosphamide', Bulletin of Experimental Biology and Medicine, vol. 170, no. 1, pp. 171-174. https://doi.org/10.1007/s10517-020-05025-y

Safonova, E. A. ; Lopatina, K. A. ; Dyagel, A. R. ; Razina, T. G. ; Krylova, S. G. ; Gur’ev, A. M. ; Belousov, M. V. ; Zueva, E. P. / Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117⁺34⁺) in the Bone Marrow of Mice Treated with Cyclophosphamide. In: Bulletin of Experimental Biology and Medicine. 2020 ; Vol. 170, No. 1. pp. 171-174.

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abstract = "Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfara L. polysaccharides to C57BL/6 mice treated with cyclophosphamide can increase the number of hematopoietic stem cells (CD117+34+) in the bone marrow.",

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AU - Safonova, E. A.

AU - Lopatina, K. A.

AU - Dyagel, A. R.

AU - Razina, T. G.

AU - Krylova, S. G.

AU - Gur’ev, A. M.

AU - Belousov, M. V.

AU - Zueva, E. P.

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AB - Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfara L. polysaccharides to C57BL/6 mice treated with cyclophosphamide can increase the number of hematopoietic stem cells (CD117+34+) in the bone marrow.

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KW - CD34

KW - cyclophosphamide

KW - flow cytometry

KW - polysaccharides

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Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117⁺34⁺) in the Bone Marrow of Mice Treated with Cyclophosphamide

Abstract

Keywords

ASJC Scopus subject areas

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