Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117+34+) in the Bone Marrow of Mice Treated with Cyclophosphamide

E. A. Safonova, K. A. Lopatina, A. R. Dyagel, T. G. Razina, S. G. Krylova, A. M. Gur’ev, M. V. Belousov, E. P. Zueva

Research output: Contribution to journalArticlepeer-review

Abstract

Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfara L. polysaccharides to C57BL/6 mice treated with cyclophosphamide can increase the number of hematopoietic stem cells (CD117+34+) in the bone marrow.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume170
Issue number1
DOIs
Publication statusPublished - Nov 2020

Keywords

  • CD117
  • CD34
  • cyclophosphamide
  • flow cytometry
  • polysaccharides

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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