Abstract
A study was made to evaluate the prospects of improving the cardiac function by electrical stimulation of the auricular branch of the vagus nerve in patients with severe chronic heart failure (CHF). Sympathetic hyperactivity and the cardiac function were evaluated by 24-hour ECG monitoring, echocardiography, and a 6-min walk test. At the time of enrollment into the study, patients had a heart rate (HR) of more than 60 bpm, a left ventricular (LV) ejection fraction (EF) of less than 40%, and CHF NYHA functional class (FC) III or IV even with well tolerated medications. Control-group patients (n = 7) did not show significant changes in the functional state of the heart after sham treatment. In the test group (n = 44), a significant increase in LV EF and a decrease in end-systolic volume were induced by electrical pulse stimulation of the auricular branch. A decrease in HR was documented in 34 patients; CHF FC decreased by one or two grades in 40 patients. The changes were assumed to reflect new balance achieved in the autonomic regulation of the heart to contribute to sustaining competence of the myocardium. Electrical pulse stimulation of the auricular branch of the vagus nerve was concluded to provide a safe and efficacious addition to drug therapy in patients with severe CHF.
| Original language | English |
|---|---|
| Pages (from-to) | 416-420 |
| Number of pages | 5 |
| Journal | Human Physiology |
| Volume | 42 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jul 2016 |
| Externally published | Yes |
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Keywords
- chronic heart failure
- coronary heart disease
- electrical stimulation of vagus nerve
- heart rate
- hyperactivation of sympathetic nervous system
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Effect of stimulating the auricular branch of the vagus nerve on the heart rate in patients with severe chronic heart failure. / Afanasiev, S. A.; Pavlyukova, E. N.; Kuzmichkina, M. A.; Anfinogenova, Y. D.; Karpov, R. S.
In: Human Physiology, Vol. 42, No. 4, 01.07.2016, p. 416-420.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of stimulating the auricular branch of the vagus nerve on the heart rate in patients with severe chronic heart failure
AU - Afanasiev, S. A.
AU - Pavlyukova, E. N.
AU - Kuzmichkina, M. A.
AU - Anfinogenova, Y. D.
AU - Karpov, R. S.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - A study was made to evaluate the prospects of improving the cardiac function by electrical stimulation of the auricular branch of the vagus nerve in patients with severe chronic heart failure (CHF). Sympathetic hyperactivity and the cardiac function were evaluated by 24-hour ECG monitoring, echocardiography, and a 6-min walk test. At the time of enrollment into the study, patients had a heart rate (HR) of more than 60 bpm, a left ventricular (LV) ejection fraction (EF) of less than 40%, and CHF NYHA functional class (FC) III or IV even with well tolerated medications. Control-group patients (n = 7) did not show significant changes in the functional state of the heart after sham treatment. In the test group (n = 44), a significant increase in LV EF and a decrease in end-systolic volume were induced by electrical pulse stimulation of the auricular branch. A decrease in HR was documented in 34 patients; CHF FC decreased by one or two grades in 40 patients. The changes were assumed to reflect new balance achieved in the autonomic regulation of the heart to contribute to sustaining competence of the myocardium. Electrical pulse stimulation of the auricular branch of the vagus nerve was concluded to provide a safe and efficacious addition to drug therapy in patients with severe CHF.
AB - A study was made to evaluate the prospects of improving the cardiac function by electrical stimulation of the auricular branch of the vagus nerve in patients with severe chronic heart failure (CHF). Sympathetic hyperactivity and the cardiac function were evaluated by 24-hour ECG monitoring, echocardiography, and a 6-min walk test. At the time of enrollment into the study, patients had a heart rate (HR) of more than 60 bpm, a left ventricular (LV) ejection fraction (EF) of less than 40%, and CHF NYHA functional class (FC) III or IV even with well tolerated medications. Control-group patients (n = 7) did not show significant changes in the functional state of the heart after sham treatment. In the test group (n = 44), a significant increase in LV EF and a decrease in end-systolic volume were induced by electrical pulse stimulation of the auricular branch. A decrease in HR was documented in 34 patients; CHF FC decreased by one or two grades in 40 patients. The changes were assumed to reflect new balance achieved in the autonomic regulation of the heart to contribute to sustaining competence of the myocardium. Electrical pulse stimulation of the auricular branch of the vagus nerve was concluded to provide a safe and efficacious addition to drug therapy in patients with severe CHF.
KW - chronic heart failure
KW - coronary heart disease
KW - electrical stimulation of vagus nerve
KW - heart rate
KW - hyperactivation of sympathetic nervous system
UR - http://www.scopus.com/inward/record.url?scp=84983371739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983371739&partnerID=8YFLogxK
U2 - 10.1134/S0362119716030026
DO - 10.1134/S0362119716030026
M3 - Article
VL - 42
SP - 416
EP - 420
JO - Human Physiology
JF - Human Physiology
SN - 0362-1197
IS - 4
ER -