Effect of radio frequency discharge plasma on surface properties and biocompatibility of polycaprolactone matrices

E. N. Bolbasov, L. V. Antonova, V. G. Matveeva, V. A. Novikov, Evgeniy Viktorovich Shesterikov, N. L. Bogomolova, A. S. Golovkin, Sergey Ivanovich Tverdokhlebov, O. L. Barbarash, L. S. Barbarash

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Surface modification of bioresorbable polymer material (polycaprolactone, PCL) with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target was investigated. Plasma treatment resulted in an increase of surface roughness of PCL, crystallite size, the surface free energy and hydrophilicity. Increased treatment time (30, 60, 150 seconds) provoked the polymer surface saturation with the sputtering target ions (calcium, phosphorus). The assessment of plasma exposure of PCL surface on bone marrow multipotent mesenchymal stromal cells behavior (BM MSCs) has been performed. Modification of the polymer surface with the abnormal glow discharge stimulated adhesion and subsequent proliferation of BM MSCs; thus, maximum values were achieved with the surface treatment for 60 s. This type of plasma modification did not affect cell viability (apoptosis, necrosis). Thus, the surface modification with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target, appear to be a promising method of surface modification of bioresorbable polymer material (PCL) for tissue engineering.

Original languageEnglish
Pages (from-to)56-63
Number of pages8
JournalBiomeditsinskaya Khimiya
Volume62
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

Fingerprint

Surface Properties
Radio
Biocompatibility
Surface properties
Surface treatment
Polymers
Glow discharges
Plasmas
Durapatite
Mesenchymal Stromal Cells
Magnetron sputtering
Bone
Bone Marrow
Hydrophilicity
Tissue Engineering
Crystallite size
Hydrophobic and Hydrophilic Interactions
Tissue engineering
Phosphorus
Free energy

Keywords

  • Biocompatibility
  • Free energy
  • Hydrophilicity
  • Polycaprolactone
  • Roughness
  • Surface modification

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of radio frequency discharge plasma on surface properties and biocompatibility of polycaprolactone matrices. / Bolbasov, E. N.; Antonova, L. V.; Matveeva, V. G.; Novikov, V. A.; Shesterikov, Evgeniy Viktorovich; Bogomolova, N. L.; Golovkin, A. S.; Tverdokhlebov, Sergey Ivanovich; Barbarash, O. L.; Barbarash, L. S.

In: Biomeditsinskaya Khimiya, Vol. 62, No. 1, 01.01.2016, p. 56-63.

Research output: Contribution to journalArticle

Bolbasov, E. N. ; Antonova, L. V. ; Matveeva, V. G. ; Novikov, V. A. ; Shesterikov, Evgeniy Viktorovich ; Bogomolova, N. L. ; Golovkin, A. S. ; Tverdokhlebov, Sergey Ivanovich ; Barbarash, O. L. ; Barbarash, L. S. / Effect of radio frequency discharge plasma on surface properties and biocompatibility of polycaprolactone matrices. In: Biomeditsinskaya Khimiya. 2016 ; Vol. 62, No. 1. pp. 56-63.
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