Effect of polylactide molecular weight on doxorubicin and temozolomide release from chitosan-grafted polylactide nanoparticles

Antonio Di Martino, Pavel Kucharczyk, Vladimir Sedlarik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this study was to examine low molecular weight chitosan-grafted polylactide nanoparticles as a drug delivery system for doxorubicin and temozolomide. We investigated the effect of polylactide molecular weight on the release kinetic and encapsulation efficiency of both drugs. Polylactide (10 kDa and 60 kDa) has been linked to chitosan via coupling reaction. Chitosan-grafted-polylactide nanoparticles were prepared via ionotropic gelation method with tripolyphosphate as a linking agent. Results such as size (150-350 nm), -potential (+25-35 mV), efficient encapsulation and prolonged release kinetic suggested that chitosan-grafted-poly lactic acid could be a great system for co-delivery of doxorubicin and temozolomide in Glioblastoma Multiforme treatment.

Original languageEnglish
Title of host publicationNANOCON 2013 - Conference Proceedings, 5th International Conference
PublisherTANGER Ltd.
Pages521-526
Number of pages6
ISBN (Electronic)9788087294475
Publication statusPublished - 1 Jan 2013
Externally publishedYes
Event5th International Conference NANOCON 2013 - Brno, Czech Republic
Duration: 16 Oct 201318 Oct 2013

Publication series

NameNANOCON 2013 - Conference Proceedings, 5th International Conference

Conference

Conference5th International Conference NANOCON 2013
CountryCzech Republic
CityBrno
Period16.10.1318.10.13

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Keywords

  • Chitosan
  • Doxorubicin
  • In vitro release
  • Polylactide
  • Temozolomide

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Materials Science(all)

Cite this

Di Martino, A., Kucharczyk, P., & Sedlarik, V. (2013). Effect of polylactide molecular weight on doxorubicin and temozolomide release from chitosan-grafted polylactide nanoparticles. In NANOCON 2013 - Conference Proceedings, 5th International Conference (pp. 521-526). (NANOCON 2013 - Conference Proceedings, 5th International Conference). TANGER Ltd..