Vliianie proizvodnykh platiny na aktivnost' mikrosomnykh NADPH-oksidoreduktaz.

Translated title of the contribution: Effect of platinum derivatives on microsomal NADPH-oxidoreductase activity

I. A. Shchepetkin, V. M. Plotnikov, V. T. Kagiia

Research output: Contribution to journalArticle

Abstract

The influence of platinum derivatives, cisplatin (cis-diamminedichloroplatinum) and imidazolplatin (cis-diimidazoledichloroplatinum) on the activity of rat liver microsomal NADPH-oxidoreductases was investigated in vitro using spectrophotometrical and chemiluminometrical methods. In the range of concentrations from 1 to 12 microM cisplatin inhibited NADPH-cytochrome c-reductase activity and NADPH/lucigenin-dependent chemiluminescence of microsomes. The 3 microM cisplatin decreased the NADPH-dependent reductase activity by 50%. At concentrations less than 2.5 mM sanazole (drug AK-2123) did not prevent the inhibiting influence of cisplatin on microsomal NADPH-dependent reductases. Imidazolplatin insignificantly inhibited NADPH-reductases. It is concluded that negligible inhibiting effect of imidazolplatin on microsomal NADPH-oxidoreductase allows us to consider this platinum derivative as a promising compound for further experimental trials as anticancer drug with low toxic action on the normal tissues of an organism.

Translated title of the contributionEffect of platinum derivatives on microsomal NADPH-oxidoreductase activity
Original languageRussian
Pages (from-to)373-381
Number of pages9
JournalVoprosy Meditsinskoj Khimii
Volume47
Issue number4
Publication statusPublished - Jul 2001
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Molecular Biology
  • Biotechnology
  • Pharmacology

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