Vliianie proizvodnykh platiny na aktivnost' mikrosomnykh NADPH-oksidoreduktaz.

Translated title of the contribution: Effect of platinum derivatives on microsomal NADPH-oxidoreductase activity

I. A. Shchepetkin, V. M. Plotnikov, V. T. Kagiia

Research output: Contribution to journalArticle

Abstract

The influence of platinum derivatives, cisplatin (cis-diamminedichloroplatinum) and imidazolplatin (cis-diimidazoledichloroplatinum) on the activity of rat liver microsomal NADPH-oxidoreductases was investigated in vitro using spectrophotometrical and chemiluminometrical methods. In the range of concentrations from 1 to 12 microM cisplatin inhibited NADPH-cytochrome c-reductase activity and NADPH/lucigenin-dependent chemiluminescence of microsomes. The 3 microM cisplatin decreased the NADPH-dependent reductase activity by 50%. At concentrations less than 2.5 mM sanazole (drug AK-2123) did not prevent the inhibiting influence of cisplatin on microsomal NADPH-dependent reductases. Imidazolplatin insignificantly inhibited NADPH-reductases. It is concluded that negligible inhibiting effect of imidazolplatin on microsomal NADPH-oxidoreductase allows us to consider this platinum derivative as a promising compound for further experimental trials as anticancer drug with low toxic action on the normal tissues of an organism.

Original languageRussian
Pages (from-to)373-381
Number of pages9
JournalVoprosy Meditsinskoj Khimii
Volume47
Issue number4
Publication statusPublished - Jul 2001
Externally publishedYes

Fingerprint

Platinum
NADP
Oxidoreductases
Derivatives
Cisplatin
Toxic Actions
NADPH-Ferrihemoprotein Reductase
Chemiluminescence
Microsomes
Luminescence
Pharmaceutical Preparations
Liver
Rats
Tissue
diimidazoldichloroplatinum

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Molecular Biology
  • Biotechnology
  • Pharmacology

Cite this

Vliianie proizvodnykh platiny na aktivnost' mikrosomnykh NADPH-oksidoreduktaz. / Shchepetkin, I. A.; Plotnikov, V. M.; Kagiia, V. T.

In: Voprosy Meditsinskoj Khimii, Vol. 47, No. 4, 07.2001, p. 373-381.

Research output: Contribution to journalArticle

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