Effect of plant polysaccharides on Th1-dependent immune response: Screening investigation

M. G. Danilets, Yu P. Bel'skii, A. M. Gur'ev, M. V. Belousov, N. V. Bel'skaya, E. S. Trofimova, E. G. Uchasova, R. R. Akhmedzhanov, A. A. Ligacheva, M. S. Yusubov, V. I. Agafonov

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


We have studied the influence of water-soluble polysaccharides isolated from Tussilago farfara L. leaves, Betula verrucosa Ehrh. leaves, Calendula officinalis L. flowers, Acorus calamus rhizomes, Inula helenium L. rhizomes, overground part of Trifolium pretense L., and overground part of Artemisia absinthium L., on Th1 immune response induced by sheep red blood cells and on NO production by murine peritoneal macrophages in vitro. All the investigated polysaccharides have stimulated a Th1 response. Polysaccharides isolated from Betula verrucosa leaves did not influence NO synthesis, while polysaccharides of Tussilago farfara leaves and Acorus calamus rhizomes stimulated NO synthase of murine macrophages on a level comparable with that of lipopolysaccharides (LPS). Polysaccharides from Inula helenium rhizomes, Calendula officinalis flowers, and overground parts of Trifolium pretense and Artemisia absinthium also stimulated NO production, but to a lower extent in comparison to LPS.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Issue number6
Publication statusPublished - 2010


  • Macrophages
  • Nitric oxide
  • Th1 response
  • Water-soluble polysaccharides

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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