Effect of plant polysaccharides on Th1-dependent immune response

Screening investigation

M. G. Danilets, Yu P. Bel'skii, A. M. Gur'ev, M. V. Belousov, N. V. Bel'skaya, E. S. Trofimova, E. G. Uchasova, R. R. Akhmedzhanov, A. A. Ligacheva, M. S. Yusubov, V. I. Agafonov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have studied the influence of water-soluble polysaccharides isolated from Tussilago farfara L. leaves, Betula verrucosa Ehrh. leaves, Calendula officinalis L. flowers, Acorus calamus rhizomes, Inula helenium L. rhizomes, overground part of Trifolium pretense L., and overground part of Artemisia absinthium L., on Th1 immune response induced by sheep red blood cells and on NO production by murine peritoneal macrophages in vitro. All the investigated polysaccharides have stimulated a Th1 response. Polysaccharides isolated from Betula verrucosa leaves did not influence NO synthesis, while polysaccharides of Tussilago farfara leaves and Acorus calamus rhizomes stimulated NO synthase of murine macrophages on a level comparable with that of lipopolysaccharides (LPS). Polysaccharides from Inula helenium rhizomes, Calendula officinalis flowers, and overground parts of Trifolium pretense and Artemisia absinthium also stimulated NO production, but to a lower extent in comparison to LPS.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume73
Issue number6
Publication statusPublished - 2010

Fingerprint

Rhizome
Polysaccharides
Screening
Tussilago
Artemisia absinthium
Inula
Acorus
Calendula
Trifolium
Betula
Macrophages
Lipopolysaccharides
Peritoneal Macrophages
Nitric Oxide Synthase
Sheep
Blood
Erythrocytes
Cells
Water
absinthium

Keywords

  • Macrophages
  • Nitric oxide
  • Th1 response
  • Water-soluble polysaccharides

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Danilets, M. G., Bel'skii, Y. P., Gur'ev, A. M., Belousov, M. V., Bel'skaya, N. V., Trofimova, E. S., ... Agafonov, V. I. (2010). Effect of plant polysaccharides on Th1-dependent immune response: Screening investigation. Eksperimental'naya i Klinicheskaya Farmakologiya, 73(6), 19-22.

Effect of plant polysaccharides on Th1-dependent immune response : Screening investigation. / Danilets, M. G.; Bel'skii, Yu P.; Gur'ev, A. M.; Belousov, M. V.; Bel'skaya, N. V.; Trofimova, E. S.; Uchasova, E. G.; Akhmedzhanov, R. R.; Ligacheva, A. A.; Yusubov, M. S.; Agafonov, V. I.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 73, No. 6, 2010, p. 19-22.

Research output: Contribution to journalArticle

Danilets, MG, Bel'skii, YP, Gur'ev, AM, Belousov, MV, Bel'skaya, NV, Trofimova, ES, Uchasova, EG, Akhmedzhanov, RR, Ligacheva, AA, Yusubov, MS & Agafonov, VI 2010, 'Effect of plant polysaccharides on Th1-dependent immune response: Screening investigation', Eksperimental'naya i Klinicheskaya Farmakologiya, vol. 73, no. 6, pp. 19-22.
Danilets, M. G. ; Bel'skii, Yu P. ; Gur'ev, A. M. ; Belousov, M. V. ; Bel'skaya, N. V. ; Trofimova, E. S. ; Uchasova, E. G. ; Akhmedzhanov, R. R. ; Ligacheva, A. A. ; Yusubov, M. S. ; Agafonov, V. I. / Effect of plant polysaccharides on Th1-dependent immune response : Screening investigation. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2010 ; Vol. 73, No. 6. pp. 19-22.
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