Effect of nitro derivatives on electromechanical coupling in ureteral smooth muscle cells

I. V. Kovalev, A. G. Popov, A. A. Panov, Yu L. Borodin, L. V. Kapilevich, Yana Jonovna Anfinogenova, M. B. Baskakov, M. A. Medvedev

Research output: Contribution to journalArticle

Abstract

Double sucrose gap experiments revealed differences in the effect of nitroglycerin and sodium nitroprusside on action potential and contraction of ureteral smooth muscle cells. Unlike sodium nitroprusside, nitroglycerin inhibited voltage-dependent Ca2+ membrane permeability. It was concluded that cGMP-independent mechanisms of the effects of nitro derivative reflect the peculiarities of excitation-contraction coupling in smooth muscles.

Original languageEnglish
Pages (from-to)455-457
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume129
Issue number5
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Ionic membrane permeability
  • Nitro derivatives
  • Smooth muscle cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Kovalev, I. V., Popov, A. G., Panov, A. A., Borodin, Y. L., Kapilevich, L. V., Anfinogenova, Y. J., Baskakov, M. B., & Medvedev, M. A. (2000). Effect of nitro derivatives on electromechanical coupling in ureteral smooth muscle cells. Bulletin of Experimental Biology and Medicine, 129(5), 455-457.