Effect of nitro derivatives on electromechanical coupling in ureteral smooth muscle cells

Abstract

Double sucrose gap experiments revealed differences in the effect of nitroglycerin and sodium nitroprusside on action potential and contraction of ureteral smooth muscle cells. Unlike sodium nitroprusside, nitroglycerin inhibited voltage-dependent Ca²⁺ membrane permeability. It was concluded that cGMP-independent mechanisms of the effects of nitro derivative reflect the peculiarities of excitation-contraction coupling in smooth muscles.

Original language	English
Pages (from-to)	455-457
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	129
Issue number	5
Publication status	Published - 2000
Externally published	Yes

Keywords

Ionic membrane permeability
Nitro derivatives
Smooth muscle cells

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Effect of nitro derivatives on electromechanical coupling in ureteral smooth muscle cells. / Kovalev, I. V.; Popov, A. G.; Panov, A. A.; Borodin, Yu L.; Kapilevich, L. V.; Anfinogenova, Yana Jonovna; Baskakov, M. B.; Medvedev, M. A.

In: Bulletin of Experimental Biology and Medicine, Vol. 129, No. 5, 2000, p. 455-457.

Research output: Contribution to journal › Article › peer-review

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abstract = "Double sucrose gap experiments revealed differences in the effect of nitroglycerin and sodium nitroprusside on action potential and contraction of ureteral smooth muscle cells. Unlike sodium nitroprusside, nitroglycerin inhibited voltage-dependent Ca2+ membrane permeability. It was concluded that cGMP-independent mechanisms of the effects of nitro derivative reflect the peculiarities of excitation-contraction coupling in smooth muscles.",

keywords = "Ionic membrane permeability, Nitro derivatives, Smooth muscle cells",

author = "Kovalev, {I. V.} and Popov, {A. G.} and Panov, {A. A.} and Borodin, {Yu L.} and Kapilevich, {L. V.} and Anfinogenova, {Yana Jonovna} and Baskakov, {M. B.} and Medvedev, {M. A.}",

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language = "English",

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AU - Kovalev, I. V.

AU - Popov, A. G.

AU - Panov, A. A.

AU - Borodin, Yu L.

AU - Kapilevich, L. V.

AU - Anfinogenova, Yana Jonovna

AU - Baskakov, M. B.

AU - Medvedev, M. A.

PY - 2000

Y1 - 2000

N2 - Double sucrose gap experiments revealed differences in the effect of nitroglycerin and sodium nitroprusside on action potential and contraction of ureteral smooth muscle cells. Unlike sodium nitroprusside, nitroglycerin inhibited voltage-dependent Ca2+ membrane permeability. It was concluded that cGMP-independent mechanisms of the effects of nitro derivative reflect the peculiarities of excitation-contraction coupling in smooth muscles.

AB - Double sucrose gap experiments revealed differences in the effect of nitroglycerin and sodium nitroprusside on action potential and contraction of ureteral smooth muscle cells. Unlike sodium nitroprusside, nitroglycerin inhibited voltage-dependent Ca2+ membrane permeability. It was concluded that cGMP-independent mechanisms of the effects of nitro derivative reflect the peculiarities of excitation-contraction coupling in smooth muscles.

KW - Ionic membrane permeability

KW - Nitro derivatives

KW - Smooth muscle cells

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AN - SCOPUS:0033786497

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JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 5

ER -

Effect of nitro derivatives on electromechanical coupling in ureteral smooth muscle cells

Abstract

Keywords

ASJC Scopus subject areas

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