Effect of Native Humic Acids from Tomsk Region Lowland Peat on Mitochrondrial Oxidative Phosphorylation Under Hypoxic Conditions

M. V. Belousov, R. R. Akhmedzhanov, M. V. Zykova, K. Y. Vasil’ev, M. S. Yusubov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Peat humic acids (PHAs) were found under experimental normobaric hypoxia with hypercapnia to normalize the activities of succinate- and NAD-dependent energy-production processes and to prevent disconnection of oxidative phosphorylation in mouse cerebral and hepatic mitochondria. The antihypoxic activity of PHAs was comparable with that of the reference antihypoxant dihydroquercetin in mouse brain and exceeded it in liver. The observed normalization by PHAs of oxidative phosphorylation in cerebral and hepatic mitochondria was probably related to their protective properties that prevented free-radical damage of cells and organelles under hypoxic conditions.

Original languageEnglish
Pages (from-to)250-253
Number of pages4
JournalPharmaceutical Chemistry Journal
Volume49
Issue number4
DOIs
Publication statusPublished - Jul 2015

Fingerprint

Humic Substances
Oxidative Phosphorylation
Soil
Liver
Mitochondria
Hypercapnia
Succinic Acid
Organelles
NAD
Free Radicals
Brain

Keywords

  • peat humic acids
  • hypoxia
  • antihypoxic activity
  • oxidative phosphorylation

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

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AU - Belousov, M. V.

AU - Akhmedzhanov, R. R.

AU - Zykova, M. V.

AU - Vasil’ev, K. Y.

AU - Yusubov, M. S.

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AB - Peat humic acids (PHAs) were found under experimental normobaric hypoxia with hypercapnia to normalize the activities of succinate- and NAD-dependent energy-production processes and to prevent disconnection of oxidative phosphorylation in mouse cerebral and hepatic mitochondria. The antihypoxic activity of PHAs was comparable with that of the reference antihypoxant dihydroquercetin in mouse brain and exceeded it in liver. The observed normalization by PHAs of oxidative phosphorylation in cerebral and hepatic mitochondria was probably related to their protective properties that prevented free-radical damage of cells and organelles under hypoxic conditions.

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