Effect of lithium hydroxybutyrate on circadian rhythms of brain serotonin content and plasma corticosteroids in reserpine-treated mice

Abstract

Lithium hydroxybutyrate (10 mg/kg daily for 10 days, intramuscularly) administered in the morning prevents reserpine-induced depression of the diurnal steroidogenesis in mice and the development of desynchronosis between circadian rhythms of serotonin in the brain and plasma corticosteroids. Evening injections result in the formation of phase-discordant 24-h periodicities, the mean values of the studied parameters being unaffected.

Original language	English
Pages (from-to)	709-712
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	124
Issue number	7
Publication status	Published - 1 Jul 1997

Keywords

Circadian rhythms
Corticosteroids
Lithium hydroxybutyrate
Reserpine
Serotonin

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Effect of lithium hydroxybutyrate on circadian rhythms of brain serotonin content and plasma corticosteroids in reserpine-treated mice",

abstract = "Lithium hydroxybutyrate (10 mg/kg daily for 10 days, intramuscularly) administered in the morning prevents reserpine-induced depression of the diurnal steroidogenesis in mice and the development of desynchronosis between circadian rhythms of serotonin in the brain and plasma corticosteroids. Evening injections result in the formation of phase-discordant 24-h periodicities, the mean values of the studied parameters being unaffected.",

keywords = "Circadian rhythms, Corticosteroids, Lithium hydroxybutyrate, Reserpine, Serotonin",

author = "Zamoshchina, {T. A.} and Saratikov, {A. S.} and Lishmanov, {Yu B.}",

year = "1997",

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AU - Zamoshchina, T. A.

AU - Saratikov, A. S.

AU - Lishmanov, Yu B.

PY - 1997/7/1

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N2 - Lithium hydroxybutyrate (10 mg/kg daily for 10 days, intramuscularly) administered in the morning prevents reserpine-induced depression of the diurnal steroidogenesis in mice and the development of desynchronosis between circadian rhythms of serotonin in the brain and plasma corticosteroids. Evening injections result in the formation of phase-discordant 24-h periodicities, the mean values of the studied parameters being unaffected.

AB - Lithium hydroxybutyrate (10 mg/kg daily for 10 days, intramuscularly) administered in the morning prevents reserpine-induced depression of the diurnal steroidogenesis in mice and the development of desynchronosis between circadian rhythms of serotonin in the brain and plasma corticosteroids. Evening injections result in the formation of phase-discordant 24-h periodicities, the mean values of the studied parameters being unaffected.

KW - Circadian rhythms

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KW - Lithium hydroxybutyrate

KW - Reserpine

KW - Serotonin

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