Effect of lithium hydroxybutyrate on circadian rhythms of brain serotonin content and plasma corticosteroids in reserpine-treated mice

T. A. Zamoshchina, A. S. Saratikov, Yu B. Lishmanov

Research output: Contribution to journalArticlepeer-review

Abstract

Lithium hydroxybutyrate (10 mg/kg daily for 10 days, intramuscularly) administered in the morning prevents reserpine-induced depression of the diurnal steroidogenesis in mice and the development of desynchronosis between circadian rhythms of serotonin in the brain and plasma corticosteroids. Evening injections result in the formation of phase-discordant 24-h periodicities, the mean values of the studied parameters being unaffected.

Original languageEnglish
Pages (from-to)709-712
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume124
Issue number7
Publication statusPublished - 1 Jul 1997

Keywords

  • Circadian rhythms
  • Corticosteroids
  • Lithium hydroxybutyrate
  • Reserpine
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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