Effect of inhibitors of cyclic nucleotide phosphodiesterases on electrical and contractile activity of smooth muscle cells

I. V. Kovalev, A. G. Popov, M. B. Baskakov, I. L. Minochenko, A. A. Kilin, Yu L. Borodin, Yana Jonovna Anfinogenova, L. V. Kapilevich, M. A. Medvedev

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Double sucrose gap experiments were carried out to study the effect of phosphodiesterase inhibitors and penetrating analogs of cyclic nucleotides on action potential and contraction of guinea pig ureteral smooth muscle cells. 3-Isobutyl-1-methylxanthine (10 μM) and dibutyryl-cAMP (20 μM) shortened the plateau of action potential and inhibited contraction of smooth muscle cells by increasing potassium permeability of their membrane. Vinpocetine (1 μM) and dibutyryl-cAMP (100 μM) strengthened contraction of smooth muscle cells and shortened action potentials by decreasing sodium permeability of their membrane.

Original languageEnglish
Pages (from-to)38-40
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume133
Issue number1
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Cyclic nucleotide phosphodiesterases
  • Membrane ionic permeability
  • Smooth muscle cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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