Abstract
Preliminary intravenous injection of peptide agonist of δ1-opioid receptors DPDPE (0.5 mg/kg) decreased the incidence of occlusion (10 min) and reperfusion (10 min) arrhythmias in rats. By contrast, δ2-opioid receptor agonist DSLET produced no effect on the incidence of arrhythmias provoked by coronary occlusion and reperfusion. Preliminary injection of selective δ-receptor antagonist ICI 174,864 (2.5 mg/kg) or TIPP[ψ] (0.5 mg/kg) completely abolished the antiarrhythmic effect of DPDPE. Stimulation of cardiac δ1-opioid receptors with DPDPE added to perfusion saline in concentrations of 0.1 and 0.5 mg/liter decreased the incidence of reperfusion arrhythmias. Addition of DPDPE to perfusion saline in a concentration of 0.1 mg/liter prevented reoxygenation destruction of cardiomyocytes. By contrast, no cardioprotective effect of this peptide was observed at a concentration of 0.5 mg/liter in perfusion saline or when it was injected intravenously. It is concluded that the cardioprotective and antiarrhythmic effects of DPDPE are caused by activation of cardiac δ1-opioid receptors.
Original language | English |
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Pages (from-to) | 359-362 |
Number of pages | 4 |
Journal | Bulletin of Experimental Biology and Medicine |
Volume | 134 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Oct 2002 |
Keywords
- Arrhythmias
- Heart
- Ischemia
- Opioid receptors
- Reperfusion
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)