Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure

Yu B. Lishmanov, N. V. Naryznaya, L. N. Maslov

Research output: Contribution to journalArticle

Abstract

Acute cold exposure of organism (4 hours at -20°C) inhibits myocardial protein syntesis and increases cortisol/insulin index in rat blood. Preliminary repeated administration in [D-Ala2, Leu5,Arg6]-enkephalin (dalargin) prevents the decrease of myocardial protein synthesis rate after cold stress and dicreases cortisol/insulin ratio. Pretreatment with naloxone at dose of 0.2 mg/kg or 2 mg/kg doesn't eliminate "anabolic" effect of dalargin. "Anabolic" effect of dalargin is suggested to be connected with -opioid receptor stimulation and change in insulin and cortisol secretion.

Original languageEnglish
Pages (from-to)230-231
Number of pages2
JournalVoprosy Meditsinskoj Khimii
Volume45
Issue number3
Publication statusPublished - 1999

Keywords

  • Enkephalins
  • Hormones
  • Myocardial proteosynthesis
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Clinical Biochemistry
  • Molecular Biology
  • Pharmacology

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