Acute cold exposure of organism (4 hours at -20°C) inhibits myocardial protein syntesis and increases cortisol/insulin index in rat blood. Preliminary repeated administration in [D-Ala2, Leu5,Arg6]-enkephalin (dalargin) prevents the decrease of myocardial protein synthesis rate after cold stress and dicreases cortisol/insulin ratio. Pretreatment with naloxone at dose of 0.2 mg/kg or 2 mg/kg doesn't eliminate "anabolic" effect of dalargin. "Anabolic" effect of dalargin is suggested to be connected with -opioid receptor stimulation and change in insulin and cortisol secretion.
|Number of pages||2|
|Journal||Voprosy Meditsinskoj Khimii|
|Publication status||Published - 1999|
- Myocardial proteosynthesis
ASJC Scopus subject areas
- Clinical Biochemistry
- Molecular Biology