Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice

K. A. Lopatina, E. A. Safonova, K. V. Nevskaya, M. N. Stakheeva, A. M. Gur’ev, E. P. Zueva, T. G. Razina, E. N. Amosova, S. G. Krylov, M. V. Belousov

Research output: Contribution to journalArticle

Abstract

Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development. The experimental preparation on the basis of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan from Acorus calamus L. produces an antitumor effect: it reduces tumor node size and the number and area of metastases after transplantation of Lewis lung carcinoma. Using flow cytometry, we demonstrated a decrease in the population of tumor cells expressing surface CD274 (PD-L1) and CD326 antigens after 20-day course of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan.

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume164
Issue number1
DOIs
Publication statusPublished - 1 Nov 2017

Fingerprint

Acorus
Lewis Lung Carcinoma
Polysaccharides
Tumors
Cells
Neoplasms
Leukocyte L1 Antigen Complex
Neoplasm Metastasis
T-cells
Flow cytometry
Population Dynamics
Immunosuppression
Immunity
Flow Cytometry
Transplantation
Tissue
T-Lymphocytes
Growth

Keywords

  • CD274
  • CD326
  • PD-L1
  • polysaccharides
  • tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice. / Lopatina, K. A.; Safonova, E. A.; Nevskaya, K. V.; Stakheeva, M. N.; Gur’ev, A. M.; Zueva, E. P.; Razina, T. G.; Amosova, E. N.; Krylov, S. G.; Belousov, M. V.

In: Bulletin of Experimental Biology and Medicine, Vol. 164, No. 1, 01.11.2017, p. 102-105.

Research output: Contribution to journalArticle

Lopatina, KA, Safonova, EA, Nevskaya, KV, Stakheeva, MN, Gur’ev, AM, Zueva, EP, Razina, TG, Amosova, EN, Krylov, SG & Belousov, MV 2017, 'Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice', Bulletin of Experimental Biology and Medicine, vol. 164, no. 1, pp. 102-105. https://doi.org/10.1007/s10517-017-3934-4
Lopatina, K. A. ; Safonova, E. A. ; Nevskaya, K. V. ; Stakheeva, M. N. ; Gur’ev, A. M. ; Zueva, E. P. ; Razina, T. G. ; Amosova, E. N. ; Krylov, S. G. ; Belousov, M. V. / Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice. In: Bulletin of Experimental Biology and Medicine. 2017 ; Vol. 164, No. 1. pp. 102-105.
@article{f0d455c6382e402c8d659e811bd53b1b,
title = "Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice",
abstract = "Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development. The experimental preparation on the basis of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan from Acorus calamus L. produces an antitumor effect: it reduces tumor node size and the number and area of metastases after transplantation of Lewis lung carcinoma. Using flow cytometry, we demonstrated a decrease in the population of tumor cells expressing surface CD274 (PD-L1) and CD326 antigens after 20-day course of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan.",
keywords = "CD274, CD326, PD-L1, polysaccharides, tumor",
author = "Lopatina, {K. A.} and Safonova, {E. A.} and Nevskaya, {K. V.} and Stakheeva, {M. N.} and Gur’ev, {A. M.} and Zueva, {E. P.} and Razina, {T. G.} and Amosova, {E. N.} and Krylov, {S. G.} and Belousov, {M. V.}",
year = "2017",
month = "11",
day = "1",
doi = "10.1007/s10517-017-3934-4",
language = "English",
volume = "164",
pages = "102--105",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice

AU - Lopatina, K. A.

AU - Safonova, E. A.

AU - Nevskaya, K. V.

AU - Stakheeva, M. N.

AU - Gur’ev, A. M.

AU - Zueva, E. P.

AU - Razina, T. G.

AU - Amosova, E. N.

AU - Krylov, S. G.

AU - Belousov, M. V.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development. The experimental preparation on the basis of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan from Acorus calamus L. produces an antitumor effect: it reduces tumor node size and the number and area of metastases after transplantation of Lewis lung carcinoma. Using flow cytometry, we demonstrated a decrease in the population of tumor cells expressing surface CD274 (PD-L1) and CD326 antigens after 20-day course of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan.

AB - Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development. The experimental preparation on the basis of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan from Acorus calamus L. produces an antitumor effect: it reduces tumor node size and the number and area of metastases after transplantation of Lewis lung carcinoma. Using flow cytometry, we demonstrated a decrease in the population of tumor cells expressing surface CD274 (PD-L1) and CD326 antigens after 20-day course of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan.

KW - CD274

KW - CD326

KW - PD-L1

KW - polysaccharides

KW - tumor

UR - http://www.scopus.com/inward/record.url?scp=85033503230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033503230&partnerID=8YFLogxK

U2 - 10.1007/s10517-017-3934-4

DO - 10.1007/s10517-017-3934-4

M3 - Article

VL - 164

SP - 102

EP - 105

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -