Effect of a novel load-bearing trabecular Nitinol scaffold on rabbit radius bone regeneration

Irena Gotman, Asaph Zaretzky, Sergey G. Psakhie, Elazar Y. Gutmanas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The research aim was to evaluate the bone regeneration capability of novel load-bearing NiTi alloy (Nitinol) scaffolds in a critical-size defect (CSD) model. High strength "trabecular Nitinol" scaffolds were prepared by PIRAC (Powder Immersion Reaction Assisted Coating) annealing of the highly porous Ni foam in Ti powder at 900°C. This was followed by PIRAC nitriding to mitigate the release of potentially toxic Ni ions. Scaffolds phase composition and microstructure were characterized by X-ray diffraction and scanning electron microscopy (SEM/EDS), and their mechanical properties were tested in compression. New Zealand white rabbits received bone defect in right radius and were divided in four groups randomly. In the control group, nothing was placed in the defect. In other groups, NiTi scaffolds were implanted in the defect: (i) as produced, (ii) loaded with bone marrow aspirate (BMA), and (iii) biomimetically CaP-coated. The animals were sacrificed after 12 weeks. The forelimbs with scaffolds were resected, fixed, sectioned and examined in SEM. New bone formation inside the scaffold was studied by EDS analysis and by the processing of backscattered electron images. Bone ingrowth into the scaffold was observed in all implant groups, mostly next to the ulna. New bone formation was strongly enhanced by BMA loading and biomimeatic CaP coating, the bone penetrating as much as 1-1.5 mm into the scaffold. The results of this preliminary study demonstrate that the newly developed high strength trabecular Nitinol scaffolds can be successfully used for bone regeneration in critical size defects.

Original languageEnglish
Title of host publicationAdvanced Materials with Hierarchical Structure for New Technologies and Reliable Structures
PublisherAmerican Institute of Physics Inc.
Volume1683
ISBN (Electronic)9780735413306
DOIs
Publication statusPublished - 27 Oct 2015
EventInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015 - Tomsk, Russian Federation
Duration: 21 Sep 201525 Sep 2015

Conference

ConferenceInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015
CountryRussian Federation
CityTomsk
Period21.9.1525.9.15

Fingerprint

rabbits
regeneration
bones
radii
defects
osteogenesis
bone marrow
high strength
coatings
submerging
scanning electron microscopy
ulna
bearing alloys
nitriding
New Zealand
foams
animals
mechanical properties
microstructure
annealing

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Gotman, I., Zaretzky, A., Psakhie, S. G., & Gutmanas, E. Y. (2015). Effect of a novel load-bearing trabecular Nitinol scaffold on rabbit radius bone regeneration. In Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures (Vol. 1683). [020243] American Institute of Physics Inc.. https://doi.org/10.1063/1.4932933

Effect of a novel load-bearing trabecular Nitinol scaffold on rabbit radius bone regeneration. / Gotman, Irena; Zaretzky, Asaph; Psakhie, Sergey G.; Gutmanas, Elazar Y.

Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures. Vol. 1683 American Institute of Physics Inc., 2015. 020243.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gotman, I, Zaretzky, A, Psakhie, SG & Gutmanas, EY 2015, Effect of a novel load-bearing trabecular Nitinol scaffold on rabbit radius bone regeneration. in Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures. vol. 1683, 020243, American Institute of Physics Inc., International Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015, Tomsk, Russian Federation, 21.9.15. https://doi.org/10.1063/1.4932933
Gotman I, Zaretzky A, Psakhie SG, Gutmanas EY. Effect of a novel load-bearing trabecular Nitinol scaffold on rabbit radius bone regeneration. In Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures. Vol. 1683. American Institute of Physics Inc. 2015. 020243 https://doi.org/10.1063/1.4932933
Gotman, Irena ; Zaretzky, Asaph ; Psakhie, Sergey G. ; Gutmanas, Elazar Y. / Effect of a novel load-bearing trabecular Nitinol scaffold on rabbit radius bone regeneration. Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures. Vol. 1683 American Institute of Physics Inc., 2015.
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