Abstract
The aim of the study was to develop the method for collecting and processing scintigraphic data to determine myocardial flow reserve by using gamma-camera with a new type detector based on Cadmium Zinc Telluride (CZT). Sixteen coronary artery disease patients and nine healthy volunteers received cardiac dynamic single-photon emission computed tomography with technetium 99m methoxyisobutylisonitrile (99mTc-MIBI) at rest and during pharmacologic stress test. Data processing involved a formation of regions of interest from the left ventricular (LV) cavity and myocardial walls to build activity-time curves. Myocardial flow reserve index was determined as a quotient of two ratios of mean myocardial counts to area under a curve peak from LV cavity during stress test and at rest. Mean values of myocardial flow reserve index were 1.86 (1.59; 2.2) in group of healthy volunteers and 1.39 (1.12; 1.69) in patients with multivessel coronary artery disease. When the value of this index was less than 1.77, the method allowed for identification of multivessel disease with sensitivity and specificity of 81.8% and 66.7%, respectively. Standard myocardial perfusion scintigraphy in combination with the method of myocardial flow reserve index determination allows for increasing diagnostic significance of the scintigraphic approach for assessment of coronary microcirculation lesions in multivessel coronary artery disease.
| Original language | English |
|---|---|
| Article number | 01080 |
| Journal | MATEC Web of Conferences |
| Volume | 79 |
| DOIs | |
| Publication status | Published - 11 Oct 2016 |
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ASJC Scopus subject areas
- Chemistry(all)
- Engineering(all)
- Materials Science(all)
Cite this
Dynamic Single-Photon Emission Computed Tomography Data Analysis : Capabilities for Determining Functional Significance of Coronary Artery Atherosclerosis. / Mochula, Andrew; Zavadovsky, Konstantin Valerievich; Andreev, Sergey; Lishmanov, Yury.
In: MATEC Web of Conferences, Vol. 79, 01080, 11.10.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dynamic Single-Photon Emission Computed Tomography Data Analysis
T2 - Capabilities for Determining Functional Significance of Coronary Artery Atherosclerosis
AU - Mochula, Andrew
AU - Zavadovsky, Konstantin Valerievich
AU - Andreev, Sergey
AU - Lishmanov, Yury
PY - 2016/10/11
Y1 - 2016/10/11
N2 - The aim of the study was to develop the method for collecting and processing scintigraphic data to determine myocardial flow reserve by using gamma-camera with a new type detector based on Cadmium Zinc Telluride (CZT). Sixteen coronary artery disease patients and nine healthy volunteers received cardiac dynamic single-photon emission computed tomography with technetium 99m methoxyisobutylisonitrile (99mTc-MIBI) at rest and during pharmacologic stress test. Data processing involved a formation of regions of interest from the left ventricular (LV) cavity and myocardial walls to build activity-time curves. Myocardial flow reserve index was determined as a quotient of two ratios of mean myocardial counts to area under a curve peak from LV cavity during stress test and at rest. Mean values of myocardial flow reserve index were 1.86 (1.59; 2.2) in group of healthy volunteers and 1.39 (1.12; 1.69) in patients with multivessel coronary artery disease. When the value of this index was less than 1.77, the method allowed for identification of multivessel disease with sensitivity and specificity of 81.8% and 66.7%, respectively. Standard myocardial perfusion scintigraphy in combination with the method of myocardial flow reserve index determination allows for increasing diagnostic significance of the scintigraphic approach for assessment of coronary microcirculation lesions in multivessel coronary artery disease.
AB - The aim of the study was to develop the method for collecting and processing scintigraphic data to determine myocardial flow reserve by using gamma-camera with a new type detector based on Cadmium Zinc Telluride (CZT). Sixteen coronary artery disease patients and nine healthy volunteers received cardiac dynamic single-photon emission computed tomography with technetium 99m methoxyisobutylisonitrile (99mTc-MIBI) at rest and during pharmacologic stress test. Data processing involved a formation of regions of interest from the left ventricular (LV) cavity and myocardial walls to build activity-time curves. Myocardial flow reserve index was determined as a quotient of two ratios of mean myocardial counts to area under a curve peak from LV cavity during stress test and at rest. Mean values of myocardial flow reserve index were 1.86 (1.59; 2.2) in group of healthy volunteers and 1.39 (1.12; 1.69) in patients with multivessel coronary artery disease. When the value of this index was less than 1.77, the method allowed for identification of multivessel disease with sensitivity and specificity of 81.8% and 66.7%, respectively. Standard myocardial perfusion scintigraphy in combination with the method of myocardial flow reserve index determination allows for increasing diagnostic significance of the scintigraphic approach for assessment of coronary microcirculation lesions in multivessel coronary artery disease.
UR - http://www.scopus.com/inward/record.url?scp=84992630751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992630751&partnerID=8YFLogxK
U2 - 10.1051/matecconf/20167901080
DO - 10.1051/matecconf/20167901080
M3 - Article
AN - SCOPUS:84992630751
VL - 79
JO - MATEC Web of Conferences
JF - MATEC Web of Conferences
M1 - 01080
ER -