Drug loaded biodegradable load-bearing nanocomposites for damaged bone repair

E. Y. Gutmanas, I. Gotman, A. Sharipova, S. G. Psakhie, S. K. Swain, R. Unger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this paper we present a short review-scientific report on processing and properties, including in vitro degradation, of load bearing biodegradable nanocomposites as well as of macroporous 3D scaffolds for bone ingrowth. Biodegradable implantable devices should slowly degrade over time and disappear with ingrown of natural bone replacing the synthetic graft. Compared to low strength biodegradable polymers, and brittle CaP ceramics, biodegradable CaP-polymer and CaP-metal nanocomposites, mimicking structure of natural bone, as well as strong and ductile metal nanocomposites can provide to implantable devices both strengths and toughness. Nanostructuring of biodegradable β-TCP (tricalcium phosphate)-polymer (PCL and PLA), β-TCP-metal (FeMg and FeAg) and of Fe-Ag composites was achieved employing high energy attrition milling of powder blends. Nanocomposite powders were consolidated to densities close to theoretical by high pressure consolidation at ambient temperature - cold sintering, with retention of nanoscale structure. The strength of developed nanocomposites was significantly higher as compared with microscale composites of the same or similar composition. Heat treatment at moderate temperatures in hydrogen flow resulted in retention of nanoscale structure and higher ductility. Degradation of developed biodegradable β-TCP-polymer, β-TCP-metal and of Fe-Ag nanocomposites was studied in physiological solutions. Immersion tests in Ringer's and saline solution for 4 weeks resulted in 4 to 10% weight loss and less than 50% decrease in compression or bending strength, the remaining strength being significantly higher than the values reported for other biodegradable materials. Nanostructuring of Fe-Ag based materials resulted also in an increase of degradation rate because of creation on galvanic Fe-Ag nanocouples. In cell culture experiments, the developed nanocomposites supported the attachment the human osteoblast cells and exhibited no signs of cytotoxicity. Interconnected system of nanopores formed during processing of nanocomposites was used for incorporation of drugs, including antibiotics and anticancer drugs, and can be used for loading of bioactive molecules enhancing bone ingrowth.

Original languageEnglish
Title of host publicationPhysics of Cancer
Subtitle of host publicationInterdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
EditorsElazar Y. Gutmanas, Oleg B. Naimark, Yurii P. Sharkeev
PublisherAmerican Institute of Physics Inc.
Volume1882
ISBN (Electronic)9780735415621
DOIs
Publication statusPublished - 28 Sep 2017
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Russian Federation
Duration: 23 May 201726 May 2017

Conference

ConferenceInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
CountryRussian Federation
CityTomsk
Period23.5.1726.5.17

Fingerprint

bones
nanocomposites
drugs
polymers
degradation
metals
osteoblasts
comminution
composite materials
antibiotics
flexural strength
consolidation
toughness
activity (biology)
ductility
microbalances
submerging
ambient temperature
attachment
sintering

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Gutmanas, E. Y., Gotman, I., Sharipova, A., Psakhie, S. G., Swain, S. K., & Unger, R. (2017). Drug loaded biodegradable load-bearing nanocomposites for damaged bone repair. In E. Y. Gutmanas, O. B. Naimark, & Y. P. Sharkeev (Eds.), Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 (Vol. 1882). [020025] American Institute of Physics Inc.. https://doi.org/10.1063/1.5001604

Drug loaded biodegradable load-bearing nanocomposites for damaged bone repair. / Gutmanas, E. Y.; Gotman, I.; Sharipova, A.; Psakhie, S. G.; Swain, S. K.; Unger, R.

Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. ed. / Elazar Y. Gutmanas; Oleg B. Naimark; Yurii P. Sharkeev. Vol. 1882 American Institute of Physics Inc., 2017. 020025.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gutmanas, EY, Gotman, I, Sharipova, A, Psakhie, SG, Swain, SK & Unger, R 2017, Drug loaded biodegradable load-bearing nanocomposites for damaged bone repair. in EY Gutmanas, OB Naimark & YP Sharkeev (eds), Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. vol. 1882, 020025, American Institute of Physics Inc., International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017, Tomsk, Russian Federation, 23.5.17. https://doi.org/10.1063/1.5001604
Gutmanas EY, Gotman I, Sharipova A, Psakhie SG, Swain SK, Unger R. Drug loaded biodegradable load-bearing nanocomposites for damaged bone repair. In Gutmanas EY, Naimark OB, Sharkeev YP, editors, Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. Vol. 1882. American Institute of Physics Inc. 2017. 020025 https://doi.org/10.1063/1.5001604
Gutmanas, E. Y. ; Gotman, I. ; Sharipova, A. ; Psakhie, S. G. ; Swain, S. K. ; Unger, R. / Drug loaded biodegradable load-bearing nanocomposites for damaged bone repair. Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017. editor / Elazar Y. Gutmanas ; Oleg B. Naimark ; Yurii P. Sharkeev. Vol. 1882 American Institute of Physics Inc., 2017.
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