Do endogenous ligands of peripheral μ- and δ-opiate receptors mediate antiarrhythmic and cardioprotective effects of Rhodiola rosea?

L. N. Maslov, Yu B. Lishmanov, A. V. Naumova, T. V. Lasukova

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Oral administration of Rhodiola rosea extract to rats (3.5 ml/kg, 8 days) prevents reperfusion arrhythmias and elicits a protective effect in experiments on isolated heart. Experiments with naloxone and ICI 174,864 suggest that the antiarrhythmic effect of R. rosea extract is mediated through activation of μ-opiate receptors in the myocardium. The cardioprotective effect of this extract is not associated with opiate receptors.

Original languageEnglish
Pages (from-to)754-756
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume124
Issue number2
DOIs
Publication statusPublished - Aug 1997

Keywords

  • μ-and δ-opiate receptors
  • adaptogens
  • arrhythmias
  • isolated heart

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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