Oral administration of Rhodiola rosea extract to rats (3.5 ml/kg, 8 days) prevents reperfusion arrhythmias and elicits a protective effect in experiments on isolated heart. Experiments with naloxone and ICI 174,864 suggest that the antiarrhythmic effect of R. rosea extract is mediated through activation of μ-opiate receptors in the myocardium. The cardioprotective effect of this extract is not associated with opiate receptors.
- μ-and δ-opiate receptors
- isolated heart
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)