Divergent endothelial function but similar platelet microvesicle responses following eccentric and concentric cycling at a similar aerobic power output

Mark Rakobowchuk, Ophélie Ritter, Eurico Nestor Wilhelm, Laurie Isacco, Malika Bouhaddi, Bruno Degano, Nicolas Tordi, Laurent Mourot

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Endothelial function and microvesicle concentration changes after acute bouts of continuous eccentric exercise have not been assessed previously nor compared with concentric exercise at similar aerobic power outputs. This method of training may be useful among some clinical populations, but acute responses are not well described. As such, 12 healthy males completed 2 experimental sessions of either 45 min of eccentric or concentric cycling at a matched aerobic power output below the ventilatory threshold. Brachial artery vascular function was assessed throughout 5 min of forearm ischemia and 3 min thereafter, before and at 5 and 40 min of recovery following each exercise session [flowmediated dilation (FMD)]. Venous blood samples were acquired before each vascular function assessment. FMD significantly decreased after eccentric cycling by 40 min of recovery (P < 0.05), but was unaltered after concentric exercise. No differences in peak hyperemic blood flow velocity occurred neither between modalities nor at any time point (P > 0.05). Platelet-derived microvesicles increased by ~20% after both exercise modalities (P < 0.05) while endothelialderived microvesicles were unchanged (P > 0.05). Moderate relationships with cardiac output, a surrogate for shear stress, and norepinephrine were apparent (P < 0.05), but there were no relationships with inflammatory or acute phase proteins. In summary, eccentric endurance exercise induced macrovascular endothelial dysfunction; however, endothelial activation determined by endothelial microvesicles did not occur suggesting that this modality may induce oxidative stress but no significant endothelial damage. In addition, the increase in platelet microvesicle concentrations may induce beneficial microvascular adaptations as suggested by previous research.

Original languageEnglish
Pages (from-to)1031-1039
Number of pages9
JournalJournal of Applied Physiology
Volume122
Issue number4
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

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Blood Vessels
Dilatation
Blood Platelets
Brachial Artery
Acute-Phase Proteins
Forearm
Cardiac Output
Norepinephrine
Oxidative Stress
Ischemia
Research
Population

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Divergent endothelial function but similar platelet microvesicle responses following eccentric and concentric cycling at a similar aerobic power output. / Rakobowchuk, Mark; Ritter, Ophélie; Wilhelm, Eurico Nestor; Isacco, Laurie; Bouhaddi, Malika; Degano, Bruno; Tordi, Nicolas; Mourot, Laurent.

In: Journal of Applied Physiology, Vol. 122, No. 4, 01.01.2017, p. 1031-1039.

Research output: Contribution to journalArticle

Rakobowchuk, Mark ; Ritter, Ophélie ; Wilhelm, Eurico Nestor ; Isacco, Laurie ; Bouhaddi, Malika ; Degano, Bruno ; Tordi, Nicolas ; Mourot, Laurent. / Divergent endothelial function but similar platelet microvesicle responses following eccentric and concentric cycling at a similar aerobic power output. In: Journal of Applied Physiology. 2017 ; Vol. 122, No. 4. pp. 1031-1039.
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