Abstract
It was compared the diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 nmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.
| Original language | English |
|---|---|
| Pages (from-to) | 20-22 |
| Number of pages | 3 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 79 |
| Issue number | 1 |
| Publication status | Published - 1 Jan 2016 |
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Keywords
- Diuretics
- Glycosides
- Preclinical investigation
ASJC Scopus subject areas
- Toxicology
- Pharmacology
Cite this
Diuretic activity of 4-O-Carboxyphenyl-D-Glucopyranoside sodium salt administered via different routes. / Smirnov, I. V.; Murashko, T. O.; Ivanov, A. A.; Nemtsev, A. O.; Postnikov, P. S.; Bondarev, A. A.; Udut, V. V.
In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 79, No. 1, 01.01.2016, p. 20-22.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diuretic activity of 4-O-Carboxyphenyl-D-Glucopyranoside sodium salt administered via different routes
AU - Smirnov, I. V.
AU - Murashko, T. O.
AU - Ivanov, A. A.
AU - Nemtsev, A. O.
AU - Postnikov, P. S.
AU - Bondarev, A. A.
AU - Udut, V. V.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - It was compared the diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 nmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.
AB - It was compared the diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 nmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.
KW - Diuretics
KW - Glycosides
KW - Preclinical investigation
UR - http://www.scopus.com/inward/record.url?scp=84971619823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971619823&partnerID=8YFLogxK
M3 - Article
C2 - 27159953
AN - SCOPUS:84971619823
VL - 79
SP - 20
EP - 22
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 1
ER -