Abstract
It was compared the diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 nmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.
Original language | English |
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Pages (from-to) | 20-22 |
Number of pages | 3 |
Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
Volume | 79 |
Issue number | 1 |
Publication status | Published - 1 Jan 2016 |
Keywords
- Diuretics
- Glycosides
- Preclinical investigation
ASJC Scopus subject areas
- Toxicology
- Pharmacology