Diuretic activity of 4-O-Carboxyphenyl-D-Glucopyranoside sodium salt administered via different routes

Abstract

It was compared the diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 nmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.

Original language	English
Pages (from-to)	20-22
Number of pages	3
Journal	Eksperimental'naya i Klinicheskaya Farmakologiya
Volume	79
Issue number	1
Publication status	Published - 1 Jan 2016

Keywords

Diuretics
Glycosides
Preclinical investigation

ASJC Scopus subject areas

Toxicology
Pharmacology

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Diuretic activity of 4-O-Carboxyphenyl-D-Glucopyranoside sodium salt administered via different routes. / Smirnov, I. V.; Murashko, T. O.; Ivanov, A. A.; Nemtsev, A. O.; Postnikov, P. S.; Bondarev, A. A.; Udut, V. V.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 79, No. 1, 01.01.2016, p. 20-22.

Research output: Contribution to journal › Article › peer-review

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title = "Diuretic activity of 4-O-Carboxyphenyl-D-Glucopyranoside sodium salt administered via different routes",

abstract = "It was compared the diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 nmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.",

keywords = "Diuretics, Glycosides, Preclinical investigation",

author = "Smirnov, {I. V.} and Murashko, {T. O.} and Ivanov, {A. A.} and Nemtsev, {A. O.} and Postnikov, {P. S.} and Bondarev, {A. A.} and Udut, {V. V.}",

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AU - Smirnov, I. V.

AU - Murashko, T. O.

AU - Ivanov, A. A.

AU - Nemtsev, A. O.

AU - Postnikov, P. S.

AU - Bondarev, A. A.

AU - Udut, V. V.

PY - 2016/1/1

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N2 - It was compared the diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 nmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.

AB - It was compared the diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 nmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.

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