Abstract
Synthetic biodegradable polymers are widely used as materials for the targeted drug delivery and controlled release devices. In order to control the rate of drug release from polymer scaffolds surface ordinary dissolution testing is performed. It includes placing a device into testing media, taking probes at determined time and estimating the drug concentration. As for prolonged release the issue is the drug degradation in test media what leads to false interpretation of results. This study was focused on the investigation of paracetamol degradation in phosphate buffer saline media for three days and its effect on the results of polymeric drug delivery system dissolution test. It was shown, that relative error in the released drug concentration evaluation can rise up to 34% depending on the exposure time and the initial probe concentration. An approach of experimental results correction is proposed.
| Original language | English |
|---|---|
| Article number | 12007 |
| Journal | IOP Conference Series: Materials Science and Engineering |
| Volume | 511 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 24 Apr 2019 |
| Event | International Scientific and Technical Youth Conference on Perspective Materials of Constructional and Medical Purpose 2018, PMCP 2018 - Tomsk, Russian Federation Duration: 26 Nov 2018 → 30 Nov 2018 |
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ASJC Scopus subject areas
- Materials Science(all)
- Engineering(all)
Cite this
Dissolution testing for prolonged-release solid dosage form containing drug substances degrading in test media. Application to polymeric delivery systems of paracetamol. / Rakina, A. A.; Spriridonova, T. I.; Tverdokhlebov, S. I.
In: IOP Conference Series: Materials Science and Engineering, Vol. 511, No. 1, 12007, 24.04.2019.Research output: Contribution to journal › Conference article
}
TY - JOUR
T1 - Dissolution testing for prolonged-release solid dosage form containing drug substances degrading in test media. Application to polymeric delivery systems of paracetamol
AU - Rakina, A. A.
AU - Spriridonova, T. I.
AU - Tverdokhlebov, S. I.
PY - 2019/4/24
Y1 - 2019/4/24
N2 - Synthetic biodegradable polymers are widely used as materials for the targeted drug delivery and controlled release devices. In order to control the rate of drug release from polymer scaffolds surface ordinary dissolution testing is performed. It includes placing a device into testing media, taking probes at determined time and estimating the drug concentration. As for prolonged release the issue is the drug degradation in test media what leads to false interpretation of results. This study was focused on the investigation of paracetamol degradation in phosphate buffer saline media for three days and its effect on the results of polymeric drug delivery system dissolution test. It was shown, that relative error in the released drug concentration evaluation can rise up to 34% depending on the exposure time and the initial probe concentration. An approach of experimental results correction is proposed.
AB - Synthetic biodegradable polymers are widely used as materials for the targeted drug delivery and controlled release devices. In order to control the rate of drug release from polymer scaffolds surface ordinary dissolution testing is performed. It includes placing a device into testing media, taking probes at determined time and estimating the drug concentration. As for prolonged release the issue is the drug degradation in test media what leads to false interpretation of results. This study was focused on the investigation of paracetamol degradation in phosphate buffer saline media for three days and its effect on the results of polymeric drug delivery system dissolution test. It was shown, that relative error in the released drug concentration evaluation can rise up to 34% depending on the exposure time and the initial probe concentration. An approach of experimental results correction is proposed.
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UR - http://www.scopus.com/inward/citedby.url?scp=85065702519&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/511/1/012007
DO - 10.1088/1757-899X/511/1/012007
M3 - Conference article
AN - SCOPUS:85065702519
VL - 511
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
SN - 1757-8981
IS - 1
M1 - 12007
ER -