Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited

Antoni Krasiński, Valery V. Fokin, K. Barry Sharpless

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Abstract

After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.

Original language	English
Pages (from-to)	1237-1240
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	8
DOIs	https://doi.org/10.1021/ol0499203
Publication status	Published - 15 Apr 2004
Externally published	Yes

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ASJC Scopus subject areas

Molecular Medicine

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Krasiński, A., Fokin, V. V., & Sharpless, K. B. (2004). Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited. Organic Letters, 6(8), 1237-1240. https://doi.org/10.1021/ol0499203

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10.1021/ol0499203