Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited

Abstract

After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.

Original language	English
Pages (from-to)	1237-1240
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	8
DOIs	https://doi.org/10.1021/ol0499203
Publication status	Published - 15 Apr 2004
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

Access to Document

10.1021/ol0499203

Fingerprint Dive into the research topics of 'Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited'. Together they form a unique fingerprint.

Cite this

@article{910ba4a02480456a955e15afaca1b371,

title = "Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited",

abstract = "After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.",

author = "Antoni Krasi{\'n}ski and Fokin, {Valery V.} and Sharpless, {K. Barry}",

year = "2004",

month = apr,

day = "15",

doi = "10.1021/ol0499203",

language = "English",

volume = "6",

pages = "1237--1240",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited

AU - Krasiński, Antoni

AU - Fokin, Valery V.

AU - Sharpless, K. Barry

PY - 2004/4/15

Y1 - 2004/4/15

N2 - After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.

AB - After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.

UR - http://www.scopus.com/inward/record.url?scp=2442698173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442698173&partnerID=8YFLogxK

U2 - 10.1021/ol0499203

DO - 10.1021/ol0499203

M3 - Article

C2 - 15070306

AN - SCOPUS:2442698173

VL - 6

SP - 1237

EP - 1240

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 8

ER -

Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this