Abstract
After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.
Original language | English |
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Pages (from-to) | 1237-1240 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 6 |
Issue number | 8 |
DOIs | |
Publication status | Published - 15 Apr 2004 |
Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Medicine
Cite this
Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited. / Krasiński, Antoni; Fokin, Valery V.; Sharpless, K. Barry.
In: Organic Letters, Vol. 6, No. 8, 15.04.2004, p. 1237-1240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited
AU - Krasiński, Antoni
AU - Fokin, Valery V.
AU - Sharpless, K. Barry
PY - 2004/4/15
Y1 - 2004/4/15
N2 - After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.
AB - After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.
UR - http://www.scopus.com/inward/record.url?scp=2442698173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2442698173&partnerID=8YFLogxK
U2 - 10.1021/ol0499203
DO - 10.1021/ol0499203
M3 - Article
C2 - 15070306
AN - SCOPUS:2442698173
VL - 6
SP - 1237
EP - 1240
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 8
ER -