Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited

Antoni Krasiński, Valery V. Fokin, K. Barry Sharpless

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.

Original languageEnglish
Pages (from-to)1237-1240
Number of pages4
JournalOrganic Letters
Volume6
Issue number8
DOIs
Publication statusPublished - 15 Apr 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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