Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited

Abstract

After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.

Original language	English
Pages (from-to)	1237-1240
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	8
DOIs	https://doi.org/10.1021/ol0499203
Publication status	Published - 15 Apr 2004
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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10.1021/ol0499203

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title = "Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited",

abstract = "After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.",

author = "Antoni Krasi{\'n}ski and Fokin, {Valery V.} and Sharpless, {K. Barry}",

year = "2004",

month = apr,

day = "15",

doi = "10.1021/ol0499203",

language = "English",

volume = "6",

pages = "1237--1240",

journal = "Organic Letters",

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AU - Krasiński, Antoni

AU - Fokin, Valery V.

AU - Sharpless, K. Barry

PY - 2004/4/15

Y1 - 2004/4/15

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AB - After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.

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