Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited

Antoni Krasiński, Valery V. Fokin, K. Barry Sharpless

Research output: Contribution to journal › Article

212 Citations (Scopus)

Abstract

After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.

Original languageEnglish
Pages (from-to)1237-1240
Number of pages4
JournalOrganic Letters
Volume6
Issue number8
DOIs
Publication statusPublished - 15 Apr 2004
Externally publishedYes

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Triazoles
Azides
alkynes
Alkynes
synthesis
products

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited. / Krasiński, Antoni; Fokin, Valery V.; Sharpless, K. Barry.

In: Organic Letters, Vol. 6, No. 8, 15.04.2004, p. 1237-1240.

Research output: Contribution to journal › Article

Krasiński, A, Fokin, VV & Sharpless, KB 2004, 'Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited', Organic Letters, vol. 6, no. 8, pp. 1237-1240. https://doi.org/10.1021/ol0499203
Krasiński A, Fokin VV, Sharpless KB. Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited. Organic Letters. 2004 Apr 15;6(8):1237-1240. https://doi.org/10.1021/ol0499203
Krasiński, Antoni ; Fokin, Valery V. ; Sharpless, K. Barry. / Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited. In: Organic Letters. 2004 ; Vol. 6, No. 8. pp. 1237-1240.
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