Abstract
After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.
| Original language | English |
|---|---|
| Pages (from-to) | 1237-1240 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 6 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 15 Apr 2004 |
| Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
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Krasiński, A., Fokin, V. V., & Sharpless, K. B. (2004). Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited. Organic Letters, 6(8), 1237-1240. https://doi.org/10.1021/ol0499203