Differential pulse voltammetric determination of paracetamol in tablet and urine samples at a micro-crystalline natural graphite-polystyrene composite film modified electrode

Abdul Rauf Khaskheli, Jan Fischer, Jiří Barek, Vlastimil Vyskočil, Sirajuddin, Muhammad Iqbal Bhanger

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

A new extremely sensitive method for the determination of paracetamol by differential pulse voltammetry (DPV) using a micro-crystalline natural graphite-polystyrene composite film modified electrode (CFE) was developed. The experimental parameters, such as pH of Britton-Robinson buffer and potentials for regeneration of the electrode surface, were optimized. Under optimized conditions in Britton-Robinson buffer (pH 4.0), linear calibration curves were obtained in the range of 0.02-100 μmol l-1 of paracetamol. The limit of determination was 0.034 μmol l-1 which shows high sensitivity of the developed method. The method was applied for the determination of paracetamol in pharmaceutical formulations and in human urine model samples.

Original languageEnglish
Pages (from-to)238-242
Number of pages5
JournalElectrochimica Acta
Volume101
DOIs
Publication statusPublished - 1 Jan 2013
Externally publishedYes

Fingerprint

Graphite
Polystyrenes
Composite films
Acetaminophen
Tablets
Crystalline materials
Electrodes
Buffers
Voltammetry
Drug products
Calibration
Pharmaceutical Preparations

Keywords

  • Determination
  • Differential pulse voltammetry
  • Graphite-polystyrene composite
  • Human urine samples
  • Modified electrode
  • Paracetamol
  • Tablet samples

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Electrochemistry

Cite this

Differential pulse voltammetric determination of paracetamol in tablet and urine samples at a micro-crystalline natural graphite-polystyrene composite film modified electrode. / Khaskheli, Abdul Rauf; Fischer, Jan; Barek, Jiří; Vyskočil, Vlastimil; Sirajuddin; Bhanger, Muhammad Iqbal.

In: Electrochimica Acta, Vol. 101, 01.01.2013, p. 238-242.

Research output: Contribution to journalArticle

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AU - Barek, Jiří

AU - Vyskočil, Vlastimil

AU - Sirajuddin,

AU - Bhanger, Muhammad Iqbal

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AB - A new extremely sensitive method for the determination of paracetamol by differential pulse voltammetry (DPV) using a micro-crystalline natural graphite-polystyrene composite film modified electrode (CFE) was developed. The experimental parameters, such as pH of Britton-Robinson buffer and potentials for regeneration of the electrode surface, were optimized. Under optimized conditions in Britton-Robinson buffer (pH 4.0), linear calibration curves were obtained in the range of 0.02-100 μmol l-1 of paracetamol. The limit of determination was 0.034 μmol l-1 which shows high sensitivity of the developed method. The method was applied for the determination of paracetamol in pharmaceutical formulations and in human urine model samples.

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