TY - JOUR
T1 - Diagnostics of 3D Scaffolds by the Method of X-Ray Phase Contrast Visualization
AU - Al'tapova, V. R.
AU - Khlusov, Igor Albertovich
AU - Karpov, Dmitry Andreevich
AU - Chen, F.
AU - Baumbach, T.
AU - Pichugin, V. F.
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Polymers are one of the most interesting classes of materials for bioengineering due to their high biocompatibility and the possibility of regulating their strength and degradation. In bioengineering, the design of a polymer scaffold determines the functional possibilities of the scaffold and its possible medical applications. Traditionally, the design of polymer scaffolds is analyzed with the help of two-dimensional visualization methods, such as optical and electron microscopy, and computer tomography. However, the x-ray region of the electromagnetic spectrum is only insignificantly absorbed by polymers and soft tissue, which means that it does not support computer tomography with sufficient contrast. The present work investigates visualization with the help of an interferometer based on the Talbot effect for three-dimensional visualization of a polymer scaffold in absorption, phase, and dark-field contrasts. A comparison of images obtained by x-ray visualization with histological sections of the scaffold is made. Phase contrast has made it possible to visualize the polymer structure and growth of soft tissues in the volume of the scaffold. In the future, it will be possible to use phase contrast for three-dimensional visualization of polymer scaffolds and soft tissues in vivo as well as in vitro.
AB - Polymers are one of the most interesting classes of materials for bioengineering due to their high biocompatibility and the possibility of regulating their strength and degradation. In bioengineering, the design of a polymer scaffold determines the functional possibilities of the scaffold and its possible medical applications. Traditionally, the design of polymer scaffolds is analyzed with the help of two-dimensional visualization methods, such as optical and electron microscopy, and computer tomography. However, the x-ray region of the electromagnetic spectrum is only insignificantly absorbed by polymers and soft tissue, which means that it does not support computer tomography with sufficient contrast. The present work investigates visualization with the help of an interferometer based on the Talbot effect for three-dimensional visualization of a polymer scaffold in absorption, phase, and dark-field contrasts. A comparison of images obtained by x-ray visualization with histological sections of the scaffold is made. Phase contrast has made it possible to visualize the polymer structure and growth of soft tissues in the volume of the scaffold. In the future, it will be possible to use phase contrast for three-dimensional visualization of polymer scaffolds and soft tissues in vivo as well as in vitro.
KW - phase-contrast visualization
KW - polymer implants
KW - synchrotron radiation
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U2 - 10.1007/s11182-014-0150-9
DO - 10.1007/s11182-014-0150-9
M3 - Article
AN - SCOPUS:84893835685
VL - 56
SP - 1116
EP - 1123
JO - Russian Physics Journal
JF - Russian Physics Journal
SN - 1064-8887
IS - 10
ER -