Diagnostics of 3D Scaffolds by the Method of X-Ray Phase Contrast Visualization

V. R. Al'tapova, Igor Albertovich Khlusov, Dmitry Andreevich Karpov, F. Chen, T. Baumbach, V. F. Pichugin

Research output: Contribution to journalArticle

Abstract

Polymers are one of the most interesting classes of materials for bioengineering due to their high biocompatibility and the possibility of regulating their strength and degradation. In bioengineering, the design of a polymer scaffold determines the functional possibilities of the scaffold and its possible medical applications. Traditionally, the design of polymer scaffolds is analyzed with the help of two-dimensional visualization methods, such as optical and electron microscopy, and computer tomography. However, the x-ray region of the electromagnetic spectrum is only insignificantly absorbed by polymers and soft tissue, which means that it does not support computer tomography with sufficient contrast. The present work investigates visualization with the help of an interferometer based on the Talbot effect for three-dimensional visualization of a polymer scaffold in absorption, phase, and dark-field contrasts. A comparison of images obtained by x-ray visualization with histological sections of the scaffold is made. Phase contrast has made it possible to visualize the polymer structure and growth of soft tissues in the volume of the scaffold. In the future, it will be possible to use phase contrast for three-dimensional visualization of polymer scaffolds and soft tissues in vivo as well as in vitro.

Original languageEnglish
Pages (from-to)1116-1123
Number of pages8
JournalRussian Physics Journal
Volume56
Issue number10
DOIs
Publication statusPublished - 1 Feb 2014

Fingerprint

phase contrast
polymers
bioengineering
x rays
tomography
electromagnetic spectra
biocompatibility
electron microscopy
interferometers
degradation
microscopy

Keywords

  • phase-contrast visualization
  • polymer implants
  • synchrotron radiation

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Diagnostics of 3D Scaffolds by the Method of X-Ray Phase Contrast Visualization. / Al'tapova, V. R.; Khlusov, Igor Albertovich; Karpov, Dmitry Andreevich; Chen, F.; Baumbach, T.; Pichugin, V. F.

In: Russian Physics Journal, Vol. 56, No. 10, 01.02.2014, p. 1116-1123.

Research output: Contribution to journalArticle

@article{a5eb976e8abf4035b9812a7fa3e1b03d,
title = "Diagnostics of 3D Scaffolds by the Method of X-Ray Phase Contrast Visualization",
abstract = "Polymers are one of the most interesting classes of materials for bioengineering due to their high biocompatibility and the possibility of regulating their strength and degradation. In bioengineering, the design of a polymer scaffold determines the functional possibilities of the scaffold and its possible medical applications. Traditionally, the design of polymer scaffolds is analyzed with the help of two-dimensional visualization methods, such as optical and electron microscopy, and computer tomography. However, the x-ray region of the electromagnetic spectrum is only insignificantly absorbed by polymers and soft tissue, which means that it does not support computer tomography with sufficient contrast. The present work investigates visualization with the help of an interferometer based on the Talbot effect for three-dimensional visualization of a polymer scaffold in absorption, phase, and dark-field contrasts. A comparison of images obtained by x-ray visualization with histological sections of the scaffold is made. Phase contrast has made it possible to visualize the polymer structure and growth of soft tissues in the volume of the scaffold. In the future, it will be possible to use phase contrast for three-dimensional visualization of polymer scaffolds and soft tissues in vivo as well as in vitro.",
keywords = "phase-contrast visualization, polymer implants, synchrotron radiation",
author = "Al'tapova, {V. R.} and Igor Albertovich Khlusov and Karpov, {Dmitry Andreevich} and F. Chen and T. Baumbach and Pichugin, {V. F.}",
year = "2014",
month = "2",
day = "1",
doi = "10.1007/s11182-014-0150-9",
language = "English",
volume = "56",
pages = "1116--1123",
journal = "Russian Physics Journal",
issn = "1064-8887",
publisher = "Consultants Bureau",
number = "10",

}

TY - JOUR

T1 - Diagnostics of 3D Scaffolds by the Method of X-Ray Phase Contrast Visualization

AU - Al'tapova, V. R.

AU - Khlusov, Igor Albertovich

AU - Karpov, Dmitry Andreevich

AU - Chen, F.

AU - Baumbach, T.

AU - Pichugin, V. F.

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Polymers are one of the most interesting classes of materials for bioengineering due to their high biocompatibility and the possibility of regulating their strength and degradation. In bioengineering, the design of a polymer scaffold determines the functional possibilities of the scaffold and its possible medical applications. Traditionally, the design of polymer scaffolds is analyzed with the help of two-dimensional visualization methods, such as optical and electron microscopy, and computer tomography. However, the x-ray region of the electromagnetic spectrum is only insignificantly absorbed by polymers and soft tissue, which means that it does not support computer tomography with sufficient contrast. The present work investigates visualization with the help of an interferometer based on the Talbot effect for three-dimensional visualization of a polymer scaffold in absorption, phase, and dark-field contrasts. A comparison of images obtained by x-ray visualization with histological sections of the scaffold is made. Phase contrast has made it possible to visualize the polymer structure and growth of soft tissues in the volume of the scaffold. In the future, it will be possible to use phase contrast for three-dimensional visualization of polymer scaffolds and soft tissues in vivo as well as in vitro.

AB - Polymers are one of the most interesting classes of materials for bioengineering due to their high biocompatibility and the possibility of regulating their strength and degradation. In bioengineering, the design of a polymer scaffold determines the functional possibilities of the scaffold and its possible medical applications. Traditionally, the design of polymer scaffolds is analyzed with the help of two-dimensional visualization methods, such as optical and electron microscopy, and computer tomography. However, the x-ray region of the electromagnetic spectrum is only insignificantly absorbed by polymers and soft tissue, which means that it does not support computer tomography with sufficient contrast. The present work investigates visualization with the help of an interferometer based on the Talbot effect for three-dimensional visualization of a polymer scaffold in absorption, phase, and dark-field contrasts. A comparison of images obtained by x-ray visualization with histological sections of the scaffold is made. Phase contrast has made it possible to visualize the polymer structure and growth of soft tissues in the volume of the scaffold. In the future, it will be possible to use phase contrast for three-dimensional visualization of polymer scaffolds and soft tissues in vivo as well as in vitro.

KW - phase-contrast visualization

KW - polymer implants

KW - synchrotron radiation

UR - http://www.scopus.com/inward/record.url?scp=84893835685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893835685&partnerID=8YFLogxK

U2 - 10.1007/s11182-014-0150-9

DO - 10.1007/s11182-014-0150-9

M3 - Article

VL - 56

SP - 1116

EP - 1123

JO - Russian Physics Journal

JF - Russian Physics Journal

SN - 1064-8887

IS - 10

ER -