Abstract
Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering, z-potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III) nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents.
| Original language | English |
|---|---|
| Title of host publication | NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application |
| Publisher | TANGER Ltd. |
| Pages | 525-529 |
| Number of pages | 5 |
| ISBN (Electronic) | 9788087294710 |
| Publication status | Published - 1 Jan 2016 |
| Event | 8th International Conference on Nanomaterials - Research and Application, NANOCON 2016 - Brno, Czech Republic Duration: 19 Oct 2016 → 21 Oct 2016 |
Publication series
| Name | NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application |
|---|
Conference
| Conference | 8th International Conference on Nanomaterials - Research and Application, NANOCON 2016 |
|---|---|
| Country | Czech Republic |
| City | Brno |
| Period | 19.10.16 → 21.10.16 |
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Keywords
- Chitosan
- Controlled release
- Doxorubicin
- Gadolinium
- Iron oxide nanoparticles
- Theranostic
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Electronic, Optical and Magnetic Materials
- Biotechnology
- Ceramics and Composites
Cite this
Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin. / Di Martino, Antonio; Guselnikova, A. Olga; Kurtukov, V. Viktor; Postnikov, S. Pavel; Sedlarik, Vladimir.
NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application. TANGER Ltd., 2016. p. 525-529 (NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin
AU - Di Martino, Antonio
AU - Guselnikova, A. Olga
AU - Kurtukov, V. Viktor
AU - Postnikov, S. Pavel
AU - Sedlarik, Vladimir
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering, z-potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III) nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents.
AB - Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering, z-potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III) nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents.
KW - Chitosan
KW - Controlled release
KW - Doxorubicin
KW - Gadolinium
KW - Iron oxide nanoparticles
KW - Theranostic
UR - http://www.scopus.com/inward/record.url?scp=85017280055&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017280055&partnerID=8YFLogxK
M3 - Conference contribution
T3 - NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application
SP - 525
EP - 529
BT - NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application
PB - TANGER Ltd.
ER -