Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin

Antonio Di Martino, A. Olga Guselnikova, V. Viktor Kurtukov, S. Pavel Postnikov, Vladimir Sedlarik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering, z-potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III) nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents.

Original languageEnglish
Title of host publicationNANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application
PublisherTANGER Ltd.
Pages525-529
Number of pages5
ISBN (Electronic)9788087294710
Publication statusPublished - 1 Jan 2016
Event8th International Conference on Nanomaterials - Research and Application, NANOCON 2016 - Brno, Czech Republic
Duration: 19 Oct 201621 Oct 2016

Publication series

NameNANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application

Conference

Conference8th International Conference on Nanomaterials - Research and Application, NANOCON 2016
CountryCzech Republic
CityBrno
Period19.10.1621.10.16

Fingerprint

Gadolinium
Chitosan
Iron oxides
Nanoparticles
Doxorubicin
Surface treatment
Magnetic hysteresis
Drug and Narcotic Control
Dynamic light scattering
Magnetic resonance
Complexation
Refraction
Encapsulation
Pharmaceutical Preparations
Magnetic resonance imaging
Contrast Media
Thermogravimetric analysis
Chlorides
Infrared spectroscopy
Spectrum Analysis

Keywords

  • Chitosan
  • Controlled release
  • Doxorubicin
  • Gadolinium
  • Iron oxide nanoparticles
  • Theranostic

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Biotechnology
  • Ceramics and Composites

Cite this

Di Martino, A., Guselnikova, A. O., Kurtukov, V. V., Postnikov, S. P., & Sedlarik, V. (2016). Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin. In NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application (pp. 525-529). (NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application). TANGER Ltd..

Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin. / Di Martino, Antonio; Guselnikova, A. Olga; Kurtukov, V. Viktor; Postnikov, S. Pavel; Sedlarik, Vladimir.

NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application. TANGER Ltd., 2016. p. 525-529 (NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Di Martino, A, Guselnikova, AO, Kurtukov, VV, Postnikov, SP & Sedlarik, V 2016, Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin. in NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application. NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application, TANGER Ltd., pp. 525-529, 8th International Conference on Nanomaterials - Research and Application, NANOCON 2016, Brno, Czech Republic, 19.10.16.
Di Martino A, Guselnikova AO, Kurtukov VV, Postnikov SP, Sedlarik V. Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin. In NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application. TANGER Ltd. 2016. p. 525-529. (NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application).
Di Martino, Antonio ; Guselnikova, A. Olga ; Kurtukov, V. Viktor ; Postnikov, S. Pavel ; Sedlarik, Vladimir. / Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin. NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application. TANGER Ltd., 2016. pp. 525-529 (NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application).
@inproceedings{043382bd65424d3391f39b2180229f28,
title = "Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin",
abstract = "Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering, z-potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III) nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents.",
keywords = "Chitosan, Controlled release, Doxorubicin, Gadolinium, Iron oxide nanoparticles, Theranostic",
author = "{Di Martino}, Antonio and Guselnikova, {A. Olga} and Kurtukov, {V. Viktor} and Postnikov, {S. Pavel} and Vladimir Sedlarik",
year = "2016",
month = "1",
day = "1",
language = "English",
series = "NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application",
publisher = "TANGER Ltd.",
pages = "525--529",
booktitle = "NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application",

}

TY - GEN

T1 - Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin

AU - Di Martino, Antonio

AU - Guselnikova, A. Olga

AU - Kurtukov, V. Viktor

AU - Postnikov, S. Pavel

AU - Sedlarik, Vladimir

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering, z-potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III) nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents.

AB - Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering, z-potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III) nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents.

KW - Chitosan

KW - Controlled release

KW - Doxorubicin

KW - Gadolinium

KW - Iron oxide nanoparticles

KW - Theranostic

UR - http://www.scopus.com/inward/record.url?scp=85017280055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017280055&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85017280055

T3 - NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application

SP - 525

EP - 529

BT - NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application

PB - TANGER Ltd.

ER -