Development of new aquaretic drug based on phenolic glycoside structure

Murashko Tatyana, Emanova Olga, Smirnov Vladimir, Ivanov Alexey, Smirnov Ivan

Research output: Contribution to journalArticle

Abstract

We studied diuretic and saluretic effects of new synthetic origin phenolic glycosides in comparison with the leader-structure arbutin. Investigation of diuretic and saluretic activity of hydroquinone-O-β-D-glucopyranoside (arbutin) 2-methoxy-4-formylphenyl-O-β-D-glucopyranoside and phenyl-O-β-D-glucopyranoside was conducted on white laboratory rats. Animals received drug with increasing dose over 14 days. Baseline diuresis after administration of 2 mL of distilled water of experimental group accepted as a control. The quantity of urine output was measured a day after administration of the test substances. The concentration of sodium and potassium ions in the urine were determined by flame photometry. The data obtained indicate that investigated glycosides has high diuretic activity. We observed dose-dependent effect of substances. The 2-methoxy-4-formylphenyl-O-β-D-glucopyranoside it is the most promising of the investigated in this study the synthetic compounds.

Original languageEnglish
Pages (from-to)6398-6401
Number of pages4
JournalJournal of Engineering and Applied Sciences
Volume12
Issue numberSpecialissue3
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Aquaretic
  • Arbutin
  • Diuretic
  • Pheholic glycoside
  • Rat
  • Saluretic

ASJC Scopus subject areas

  • Engineering(all)

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