Development of effective strategies for the radionuclide incorporation into CaCO3particles for in vivo studies

Elena N. Gerasimova, Dmitrii Antuganov, Yana V. Tarakanchikova, Timofey E. Karpov, Tatiana V. Mashel, Oleksii O. Peltek, Alexandre Nominé, Stéphanie Bruyere, Yulia A. Kondratenko, Albert R. Muslimov, Alexander S. Timin, Mikhail V. Zyuzin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Core-shell calcium carbonate (CaCO3) particles of different sizes, and coated with biocompatible polymers via layer-by-layer method were loaded with a model radionuclide 68Ga using different strategies. The obtained radiolabeled particles were characterized and their biodistribution was tested after intravenous injection in rats. The obtained data demonstrate the size-dependent organ accumulation of particles as verified with positron emission tomography and computerized tomography.

Original languageEnglish
Title of host publication5th International Conference on Metamaterials and Nanophotonics, METANANO 2020
EditorsPavel Belov, Mihail Petrov
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440340
DOIs
Publication statusPublished - 8 Dec 2020
Event5th International Conference on Metamaterials and Nanophotonics, METANANO 2020 - St. Petersburg, Virtual, Russian Federation
Duration: 14 Sep 202018 Sep 2020

Publication series

NameAIP Conference Proceedings
Volume2300
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Conference on Metamaterials and Nanophotonics, METANANO 2020
CountryRussian Federation
CitySt. Petersburg, Virtual
Period14.9.2018.9.20

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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