Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems

E. Chudinova, M. Surmeneva, A. Koptyug, V. Sokolova, O. Prymak, S. Bouckercha, M. Epple, R. Surmenev

Research output: Contribution to journalConference article

Abstract

In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 m and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.

Original languageEnglish
Article number012056
JournalIOP Conference Series: Materials Science and Engineering
Volume597
Issue number1
DOIs
Publication statusPublished - 23 Aug 2019
Event16th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2019 - Tomsk, Russian Federation
Duration: 23 Apr 201926 Apr 2019

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Biochemistry
Calcium carbonate
Dynamic light scattering
Zeta potential
Biotechnology
Encapsulation
Dexamethasone
Medicine
Capsules
Hydrodynamics
Spectroscopy
Infrared radiation
Proteins
Scanning electron microscopy
Polymers
Calcium Carbonate
Drug Delivery Systems
fluorescein isothiocyanate bovine serum albumin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

Cite this

Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems. / Chudinova, E.; Surmeneva, M.; Koptyug, A.; Sokolova, V.; Prymak, O.; Bouckercha, S.; Epple, M.; Surmenev, R.

In: IOP Conference Series: Materials Science and Engineering, Vol. 597, No. 1, 012056, 23.08.2019.

Research output: Contribution to journalConference article

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AU - Prymak, O.

AU - Bouckercha, S.

AU - Epple, M.

AU - Surmenev, R.

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