Abstract
In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 m and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.
| Original language | English |
|---|---|
| Article number | 012056 |
| Journal | IOP Conference Series: Materials Science and Engineering |
| Volume | 597 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 23 Aug 2019 |
| Event | 16th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2019 - Tomsk, Russian Federation Duration: 23 Apr 2019 → 26 Apr 2019 |
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ASJC Scopus subject areas
- Materials Science(all)
- Engineering(all)
Cite this
Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems. / Chudinova, E.; Surmeneva, M.; Koptyug, A.; Sokolova, V.; Prymak, O.; Bouckercha, S.; Epple, M.; Surmenev, R.
In: IOP Conference Series: Materials Science and Engineering, Vol. 597, No. 1, 012056, 23.08.2019.Research output: Contribution to journal › Conference article
}
TY - JOUR
T1 - Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems
AU - Chudinova, E.
AU - Surmeneva, M.
AU - Koptyug, A.
AU - Sokolova, V.
AU - Prymak, O.
AU - Bouckercha, S.
AU - Epple, M.
AU - Surmenev, R.
PY - 2019/8/23
Y1 - 2019/8/23
N2 - In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 m and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.
AB - In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 m and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.
UR - http://www.scopus.com/inward/record.url?scp=85073635032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073635032&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/597/1/012056
DO - 10.1088/1757-899X/597/1/012056
M3 - Conference article
AN - SCOPUS:85073635032
VL - 597
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
SN - 1757-8981
IS - 1
M1 - 012056
ER -