Abstract
New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min-1, injected volume 0.1 cm3, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10-6 mol dm-3 for DPV and 3.1 × 10-7 mol dm-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). Graphical abstract: [Figure not available: see fulltext.]
| Original language | English |
|---|---|
| Pages (from-to) | 1211-1215 |
| Number of pages | 5 |
| Journal | Monatshefte fur Chemie |
| Volume | 146 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 29 Aug 2015 |
| Externally published | Yes |
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Keywords
- Amperometry
- Electrochemistry
- Pharmaceuticals
- Voltammetry
ASJC Scopus subject areas
- Chemistry(all)
Cite this
Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection. / Mika, Jan; Moreira, Josino C.; Nemeckova, Andrea; Zima, Jiri; Barek, Jiri; Dejmkova, Hana.
In: Monatshefte fur Chemie, Vol. 146, No. 8, 29.08.2015, p. 1211-1215.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection
AU - Mika, Jan
AU - Moreira, Josino C.
AU - Nemeckova, Andrea
AU - Zima, Jiri
AU - Barek, Jiri
AU - Dejmkova, Hana
PY - 2015/8/29
Y1 - 2015/8/29
N2 - New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min-1, injected volume 0.1 cm3, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10-6 mol dm-3 for DPV and 3.1 × 10-7 mol dm-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). Graphical abstract: [Figure not available: see fulltext.]
AB - New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min-1, injected volume 0.1 cm3, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10-6 mol dm-3 for DPV and 3.1 × 10-7 mol dm-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). Graphical abstract: [Figure not available: see fulltext.]
KW - Amperometry
KW - Electrochemistry
KW - Pharmaceuticals
KW - Voltammetry
UR - http://www.scopus.com/inward/record.url?scp=84927555965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927555965&partnerID=8YFLogxK
U2 - 10.1007/s00706-015-1469-9
DO - 10.1007/s00706-015-1469-9
M3 - Article
AN - SCOPUS:84927555965
VL - 146
SP - 1211
EP - 1215
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
SN - 0026-9247
IS - 8
ER -