Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection

Jan Mika, Josino C. Moreira, Andrea Nemeckova, Jiri Zima, Jiri Barek, Hana Dejmkova

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min-1, injected volume 0.1 cm3, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10-6 mol dm-3 for DPV and 3.1 × 10-7 mol dm-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1211-1215
Number of pages5
JournalMonatshefte fur Chemie
Volume146
Issue number8
DOIs
Publication statusPublished - 29 Aug 2015
Externally publishedYes

Keywords

  • Amperometry
  • Electrochemistry
  • Pharmaceuticals
  • Voltammetry

ASJC Scopus subject areas

  • Chemistry(all)

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