Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection

Jan Mika, Josino C. Moreira, Andrea Nemeckova, Jiri Zima, Jiri Barek, Hana Dejmkova

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min-1, injected volume 0.1 cm3, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10-6 mol dm-3 for DPV and 3.1 × 10-7 mol dm-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1211-1215
Number of pages5
JournalMonatshefte fur Chemie
Volume146
Issue number8
DOIs
Publication statusPublished - 29 Aug 2015
Externally publishedYes

Fingerprint

Bromhexine
Glassy carbon
Voltammetry
Ointments
Electrodes
Methanol
Buffers
Electrolytes
Tablets
Flow rate
Pharmaceutical Preparations

Keywords

  • Amperometry
  • Electrochemistry
  • Pharmaceuticals
  • Voltammetry

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection. / Mika, Jan; Moreira, Josino C.; Nemeckova, Andrea; Zima, Jiri; Barek, Jiri; Dejmkova, Hana.

In: Monatshefte fur Chemie, Vol. 146, No. 8, 29.08.2015, p. 1211-1215.

Research output: Contribution to journalArticle

Mika, Jan ; Moreira, Josino C. ; Nemeckova, Andrea ; Zima, Jiri ; Barek, Jiri ; Dejmkova, Hana. / Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection. In: Monatshefte fur Chemie. 2015 ; Vol. 146, No. 8. pp. 1211-1215.
@article{5ef73d9e469d49a3ac3986b1f6f276fc,
title = "Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection",
abstract = "New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min-1, injected volume 0.1 cm3, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10-6 mol dm-3 for DPV and 3.1 × 10-7 mol dm-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). Graphical abstract: [Figure not available: see fulltext.]",
keywords = "Amperometry, Electrochemistry, Pharmaceuticals, Voltammetry",
author = "Jan Mika and Moreira, {Josino C.} and Andrea Nemeckova and Jiri Zima and Jiri Barek and Hana Dejmkova",
year = "2015",
month = "8",
day = "29",
doi = "10.1007/s00706-015-1469-9",
language = "English",
volume = "146",
pages = "1211--1215",
journal = "Monatshefte fur Chemie",
issn = "0026-9247",
publisher = "Springer Wien",
number = "8",

}

TY - JOUR

T1 - Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection

AU - Mika, Jan

AU - Moreira, Josino C.

AU - Nemeckova, Andrea

AU - Zima, Jiri

AU - Barek, Jiri

AU - Dejmkova, Hana

PY - 2015/8/29

Y1 - 2015/8/29

N2 - New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min-1, injected volume 0.1 cm3, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10-6 mol dm-3 for DPV and 3.1 × 10-7 mol dm-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). Graphical abstract: [Figure not available: see fulltext.]

AB - New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min-1, injected volume 0.1 cm3, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10-6 mol dm-3 for DPV and 3.1 × 10-7 mol dm-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). Graphical abstract: [Figure not available: see fulltext.]

KW - Amperometry

KW - Electrochemistry

KW - Pharmaceuticals

KW - Voltammetry

UR - http://www.scopus.com/inward/record.url?scp=84927555965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927555965&partnerID=8YFLogxK

U2 - 10.1007/s00706-015-1469-9

DO - 10.1007/s00706-015-1469-9

M3 - Article

VL - 146

SP - 1211

EP - 1215

JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

SN - 0026-9247

IS - 8

ER -