Abstract
New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min-1, injected volume 0.1 cm3, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10-6 mol dm-3 for DPV and 3.1 × 10-7 mol dm-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). Graphical abstract: [Figure not available: see fulltext.]
Original language | English |
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Pages (from-to) | 1211-1215 |
Number of pages | 5 |
Journal | Monatshefte fur Chemie |
Volume | 146 |
Issue number | 8 |
DOIs | |
Publication status | Published - 29 Aug 2015 |
Externally published | Yes |
Keywords
- Amperometry
- Electrochemistry
- Pharmaceuticals
- Voltammetry
ASJC Scopus subject areas
- Chemistry(all)