Abstract
A new method for benzocaine determination employing FIA and HPLC with electrochemical detection on a carbon paste electrode was developed. The optimum conditions for the determination were found. Carrier solution for FIA consisted of B-R buffer pH4 (80% methanol, v/v) and used flow rate was 1.0mLmin-1. Mobile phase for HPLC consisted of B-R buffer pH4 (75% methanol, v/v) with flow rate 0.4mLmin-1. Working potential of +1.2V was employed. Practical applicability of the methods was tested on the determination of benzocaine in selected pharmaceuticals. The results were in agreement with results obtained using spectrophotometric detection and with one exception also with the content declared by the manufacturer.
| Original language | English |
|---|---|
| Pages (from-to) | 662-666 |
| Number of pages | 5 |
| Journal | Electroanalysis |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Mar 2011 |
| Externally published | Yes |
Keywords
- Amperometric detection
- Carbon paste electrode
- FIA
- HPLC
- Pharmaceuticals
ASJC Scopus subject areas
- Analytical Chemistry
- Electrochemistry
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Cite this
Dejmkova, H., Vokalova, V., Zima, J., & Barek, J. (2011). Determination of Benzocaine Using HPLC and FIA with Amperometric Detection on a Carbon Paste Electrode. Electroanalysis, 23(3), 662-666. https://doi.org/10.1002/elan.201000646