Desulfurization of sultams with simultaneous methylenation

Victor O. Rogachev, Sandra Merten, Tobias Seiser, Olga Kataeva, Peter Metz

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    5 Citations (Scopus)


    Alkylation of γ- and δ-sultams with (iodomethyl)trimethylsilane followed by treatment of the resultant silanes with tetrabutylammonium fluoride gave rise to sulfur-free unsaturated amines. In particular, N-THP substituted sultams were found to be useful substrates for the alkylation event. A corresponding one-pot transformation involving sultam α-alkylation with (iodomethyl)magnesium chloride is also reported.

    Original languageEnglish
    Pages (from-to)133-136
    Number of pages4
    JournalTetrahedron Letters
    Issue number1
    Publication statusPublished - 1 Jan 2008


    • Alkenylation
    • Alkylation
    • Desulfurization
    • Sultams

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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  • Cite this

    Rogachev, V. O., Merten, S., Seiser, T., Kataeva, O., & Metz, P. (2008). Desulfurization of sultams with simultaneous methylenation. Tetrahedron Letters, 49(1), 133-136.