Abstract
Alkylation of γ- and δ-sultams with (iodomethyl)trimethylsilane followed by treatment of the resultant silanes with tetrabutylammonium fluoride gave rise to sulfur-free unsaturated amines. In particular, N-THP substituted sultams were found to be useful substrates for the alkylation event. A corresponding one-pot transformation involving sultam α-alkylation with (iodomethyl)magnesium chloride is also reported.
Original language | English |
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Pages (from-to) | 133-136 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 49 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2008 |
Keywords
- Alkenylation
- Alkylation
- Desulfurization
- Sultams
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry