Design, synthesis and evaluation of a new Mn – Contrast agent for MR imaging of myocardium based on the DTPA-phenylpentadecanoic acid complex

Maxim L. Belyanin, Elena V. Stepanova, Rashid R. Valiev, Victor D. Filimonov, Vladimir Y. Usov, Oleg Y. Borodin, Hans Ågren

Research output: Contribution to journalArticle

4 Citations (Scopus)


In the present paper we describe the first synthesis and evaluation of a novel Mn (II) complex (DTPA-PPDA Mn (II)) which contains a C-15 fatty acid moiety that has high affinity to the heart muscle. The complexation energy of DTPA-PPDA Mn (II) evaluated by quantum chemistry methodology indicates that it essentially exceeds the corresponding value for the known DTPA Mn (II) complex. Molecular docking revealed that the affinity of the designed complex to the heart-type transport protein H-FABP well exceeds that of lauric acid. Phantom experiments in low-field MRI the designed contrast agent provides MR imaging comparable to gadopentetic acid.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalChemical Physics Letters
Publication statusPublished - 16 Nov 2016



  • DFT
  • Gadolinium
  • Manganese
  • Molecular docking
  • MRI-contrast agent

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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