Decreased luminol-dependent chemiluminescence response of neutrophils to recombinant human tumour necrosis factor in patients with gastric cancer

I. A. Schepetkin, N. V. Cherdyntseva, E. V. Borunov, I. L. Skutina, S. A. Naumov

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8 Citations (Scopus)

Abstract

Production of reactive oxygen species by neutrophils was analysed by a chemiluminometric method in the presence of luminol in ten healthy donors, eight patients with gastric cancer and ten patients with gastric precancer. The neutrophil chemiluminominescence response to recombinant tumour necrosis factor (rTNF) was almost five times lower in the gastric patients when compared with healthy donors and precancer patients. The chemiluminescence response to zymosan was decreased only in the gastric cancer patients with chemiluminescence index activation (CTNF)

Original languageEnglish
Pages (from-to)172-174
Number of pages3
JournalJournal of Cancer Research and Clinical Oncology
Volume117
Issue number2
DOIs
Publication statusPublished - Mar 1991
Externally publishedYes

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Keywords

  • Chemiluminescence
  • Gastric cancer
  • Neutrophil
  • Tumour Necrosis Factor
  • Zymosan

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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