DDAO Controlled Synthesis of Organo-Modified Silica Nanoparticles with Encapsulated Fluorescent Boron Dipyrrins and Study of Their Uptake by Cancerous Cells

Aleksandr A. Goncharenko, Ilya A. Tarasyuk, Yuriy S. Marfin, Kirill V. Grzhegorzhevskii, Albert R. Muslimov, Andrey B. Bondarenko, Maxim D. Lebedev, Ilya A. Kuz'min, Artur S. Vashurin, Kirill V. Lepik, Alexander S. Timin, Evgeniy V. Rumyantsev

Research output: Contribution to journalArticle

Abstract

The design of cargo carriers with high biocompatibility, unique morphological characteristics, and capability of strong bonding of fluorescent dye is highly important for the development of a platform for smart imaging and diagnostics. In this paper, BODIPY-doped silica nanoparticles were prepared through a "one-pot" soft-template method using a sol-gel process. Several sol-gel precursors have been used in sol-gel synthesis in the presence of soft-template to obtain the silica-based materials with the most appropriate morphological features for the immobilization of BODIPY molecules. Obtained silica particles have been shown to be non-cytotoxic and can be effectively internalized into the cervical cancer cell line (HeLa). The described method of synthesis allows us to obtain silica-based carriers with an immobilized fluorescent dye that provide the possibility for real-time imaging and detection of these carriers.

Original languageEnglish
JournalMolecules (Basel, Switzerland)
Volume25
Issue number17
DOIs
Publication statusPublished - 21 Aug 2020

Keywords

  • BODIPY
  • oil-in-water
  • one-pot synthesis
  • silica nanoparticles
  • soft-template

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Goncharenko, A. A., Tarasyuk, I. A., Marfin, Y. S., Grzhegorzhevskii, K. V., Muslimov, A. R., Bondarenko, A. B., Lebedev, M. D., Kuz'min, I. A., Vashurin, A. S., Lepik, K. V., Timin, A. S., & Rumyantsev, E. V. (2020). DDAO Controlled Synthesis of Organo-Modified Silica Nanoparticles with Encapsulated Fluorescent Boron Dipyrrins and Study of Their Uptake by Cancerous Cells. Molecules (Basel, Switzerland), 25(17). https://doi.org/10.3390/molecules25173802