D-opioid receptors agonists prevent in vivo reperfusive heart injury in experiment

A. V. Krylatov, O. E. Vaizova, M. V. Belousov, S. V. Pozdnyakova, E. A. Nesterov, P. G. Madonov

Research output: Contribution to journalArticle

Abstract

Rats anesthetized by chloralose were subjected to coronary artery occlusion (45 min) and, 5 minutes before reperfusion (120 min), treated intravenously with various d-opioid receptor agonists including deltorphin II at a dose of 150 nmol/kg; p-Cl-Phe-DPDPE at 150 and 1500 nmol/kg; DPDPE at 1500 nmol/kg; and BW 373 at 230 and 2300 nmol/kg. The response was evaluated by the ratio of the infarct zone (IZ) area to area at risk (AAR). It was found that deltotphin II at a dose of 150 nmol/kg, Cl-DPDE at a dose of 1500 nmol/kg, and BW373 at a dose of to 2300 nmol/kg reduced the IS/AAR ratio by 40% relative to control. Deltorphin II exhibited the protective effect at a 10 times lower dose than other drugs, which allows this d-opioid receptor agonist to be considered as prototype in creating medicines for the treatment of acute myocardial infarction.

Original languageEnglish
Pages (from-to)8-10
Number of pages3
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume82
Issue number11
DOIs
Publication statusPublished - 2019

Keywords

  • Myocardial infarction
  • Opioid receptors
  • Post-conditioning
  • Rats
  • Reperfusion

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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