CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects

S. A. Ivanova, M. L. Filipenko, N. M. Vyalova, E. N. Voronina, I. V. Pozhidaev, D. Z. Osmanova, M. V. Ivanov, O. Y. Fedorenko, A. V. Semke, N. A. Bokhan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalBulletin of Experimental Biology and Medicine
DOIs
Publication statusAccepted/In press - 29 Mar 2016

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Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP2D6
Drug-Related Side Effects and Adverse Reactions
Polymorphism
Antipsychotic Agents
Genes
Schizophrenia
Association reactions
Debrisoquin
Hyperprolactinemia
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Genotype
Pharmaceutical Preparations
Tardive Dyskinesia
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ivanova, S. A., Filipenko, M. L., Vyalova, N. M., Voronina, E. N., Pozhidaev, I. V., Osmanova, D. Z., ... Bokhan, N. A. (Accepted/In press). CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. Bulletin of Experimental Biology and Medicine, 1-4. https://doi.org/10.1007/s10517-016-3250-4

CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. / Ivanova, S. A.; Filipenko, M. L.; Vyalova, N. M.; Voronina, E. N.; Pozhidaev, I. V.; Osmanova, D. Z.; Ivanov, M. V.; Fedorenko, O. Y.; Semke, A. V.; Bokhan, N. A.

In: Bulletin of Experimental Biology and Medicine, 29.03.2016, p. 1-4.

Research output: Contribution to journalArticle

Ivanova, SA, Filipenko, ML, Vyalova, NM, Voronina, EN, Pozhidaev, IV, Osmanova, DZ, Ivanov, MV, Fedorenko, OY, Semke, AV & Bokhan, NA 2016, 'CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects', Bulletin of Experimental Biology and Medicine, pp. 1-4. https://doi.org/10.1007/s10517-016-3250-4
Ivanova, S. A. ; Filipenko, M. L. ; Vyalova, N. M. ; Voronina, E. N. ; Pozhidaev, I. V. ; Osmanova, D. Z. ; Ivanov, M. V. ; Fedorenko, O. Y. ; Semke, A. V. ; Bokhan, N. A. / CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. In: Bulletin of Experimental Biology and Medicine. 2016 ; pp. 1-4.
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