Abstract
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
Original language | English |
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Pages (from-to) | 1-4 |
Number of pages | 4 |
Journal | Bulletin of Experimental Biology and Medicine |
DOIs | |
Publication status | Accepted/In press - 29 Mar 2016 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. / Ivanova, S. A.; Filipenko, M. L.; Vyalova, N. M.; Voronina, E. N.; Pozhidaev, I. V.; Osmanova, D. Z.; Ivanov, M. V.; Fedorenko, O. Y.; Semke, A. V.; Bokhan, N. A.
In: Bulletin of Experimental Biology and Medicine, 29.03.2016, p. 1-4.Research output: Contribution to journal › Article
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TY - JOUR
T1 - CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects
AU - Ivanova, S. A.
AU - Filipenko, M. L.
AU - Vyalova, N. M.
AU - Voronina, E. N.
AU - Pozhidaev, I. V.
AU - Osmanova, D. Z.
AU - Ivanov, M. V.
AU - Fedorenko, O. Y.
AU - Semke, A. V.
AU - Bokhan, N. A.
PY - 2016/3/29
Y1 - 2016/3/29
N2 - Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
AB - Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
UR - http://www.scopus.com/inward/record.url?scp=84961613738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961613738&partnerID=8YFLogxK
U2 - 10.1007/s10517-016-3250-4
DO - 10.1007/s10517-016-3250-4
M3 - Article
AN - SCOPUS:84961613738
SP - 1
EP - 4
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
ER -