CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects

S. A. Ivanova, M. L. Filipenko, N. M. Vyalova, E. N. Voronina, I. V. Pozhidaev, D. Z. Osmanova, M. V. Ivanov, O. Y. Fedorenko, A. V. Semke, N. A. Bokhan

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Abstract

Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
DOIs	https://doi.org/10.1007/s10517-016-3250-4
Publication status	Accepted/In press - 29 Mar 2016

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/s10517-016-3250-4

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Ivanova, S. A., Filipenko, M. L., Vyalova, N. M., Voronina, E. N., Pozhidaev, I. V., Osmanova, D. Z., Ivanov, M. V., Fedorenko, O. Y., Semke, A. V., & Bokhan, N. A. (Accepted/In press). CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. Bulletin of Experimental Biology and Medicine, 1-4. https://doi.org/10.1007/s10517-016-3250-4

CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. / Ivanova, S. A.; Filipenko, M. L.; Vyalova, N. M.; Voronina, E. N.; Pozhidaev, I. V.; Osmanova, D. Z.; Ivanov, M. V.; Fedorenko, O. Y.; Semke, A. V.; Bokhan, N. A.

In: Bulletin of Experimental Biology and Medicine, 29.03.2016, p. 1-4.

Research output: Contribution to journal › Article › peer-review

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abstract = "Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.",

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AU - Ivanova, S. A.

AU - Filipenko, M. L.

AU - Vyalova, N. M.

AU - Voronina, E. N.

AU - Pozhidaev, I. V.

AU - Osmanova, D. Z.

AU - Ivanov, M. V.

AU - Fedorenko, O. Y.

AU - Semke, A. V.

AU - Bokhan, N. A.

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AB - Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.

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CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects

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