Current outlook on radionuclide delivery systems: From design consideration to translation into clinics

Oleksii O. Peltek, Albert R. Muslimov, Mikhail V. Zyuzin, Alexander S. Timin

Research output: Contribution to journalReview article

Abstract

Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed.

Original languageEnglish
Article number90
JournalJournal of Nanobiotechnology
Volume17
Issue number1
DOIs
Publication statusPublished - 21 Aug 2019

Fingerprint

Radioisotopes
Multimodal Imaging
Immunoglobulin Fragments
Monoclonal antibodies
Radiopharmaceuticals
Microspheres
Nanoparticles
Curing
Monoclonal Antibodies
Imaging techniques
Therapeutics

Keywords

  • Diagnostic and therapeutic radionuclides
  • Drug carrier systems
  • Microspheres
  • Monoclonal antibodies
  • Multimodal imaging
  • Nanoparticles
  • Nuclear medicine
  • Radiopharmaceuticals
  • Theranostics

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Applied Microbiology and Biotechnology
  • Pharmaceutical Science

Cite this

Current outlook on radionuclide delivery systems : From design consideration to translation into clinics. / Peltek, Oleksii O.; Muslimov, Albert R.; Zyuzin, Mikhail V.; Timin, Alexander S.

In: Journal of Nanobiotechnology, Vol. 17, No. 1, 90, 21.08.2019.

Research output: Contribution to journalReview article

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