Cryotherapy in inflammatory rheumatic diseases: A systematic review

Xavier Guillot, Nicolas Tordi, Laurent Mourot, Céline Demougeot, Benoît Dugué, Clément Prati, Daniel Wendling

Research output: Contribution to journalReview article

56 Citations (Scopus)

Abstract

The aim of this article was to review current evidence about cryotherapy in inflammatory rheumatic diseases (therapeutic and biological effects). For therapeutic effects, we performed a systematic review (PubMed, EMBASE, Cochrane Library, LILACS databases, unpublished data) and selected studies including non-operated and non-infected arthritic patients treated with local cryotherapy or whole-body cryotherapy. By pooling 6 studies including 257 rheumatoid arthritis (RA) patients, we showed a significant decrease in pain visual analogic scale (mm) and 28-joint disease activity score after chronic cryotherapy in RA patients. For molecular pathways, local cryotherapy induces an intrajoint temperature decrease, which might downregulate several mediators involved in joint inflammation and destruction (cytokines, cartilage-degrading enzymes, proangiogenic factors), but studies in RA are rare. Cryotherapy should be included in RA therapeutic strategies as an adjunct therapy, with potential corticosteroid and nonsteroidal anti-inflammatory drug dose-sparing effects. However, techniques and protocols should be more precisely defined in randomized controlled trials with stronger methodology.

Original languageEnglish
Pages (from-to)281-294
Number of pages14
JournalExpert Review of Clinical Immunology
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Feb 2014
Externally publishedYes

Keywords

  • cryotherapy
  • cytokines
  • DAS28
  • enzymes
  • pain VAS

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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