Abstract
α-Hydroxy ketones are a series of biologically active fragments in nature as well as important synthons for organic chemistry. Herein, an AgOAc/1-ethyl-3-methylimidazolium acetate ionic liquid system was developed for the CO2-promoted hydration of propargylic alcohols and H2O to produce α-hydroxy ketones. Diverse desired products could be obtained in satisfactory yields under 1 bar of CO2 pressure with the catalysis of only a trace amount of silver (0.005-0.25 mol %), which is the lowest level ever reported for the metal-catalyzed systems. In particular, this system had robust recyclability, and it could be reused effectively at least 5 times. Furthermore, an unprecedented turnover number (TON) of 9200 was achieved, which is considered to be the highest TON ever reached for this hydration.
Original language | English |
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Pages (from-to) | 8148-8155 |
Number of pages | 8 |
Journal | ACS Sustainable Chemistry and Engineering |
Volume | 8 |
Issue number | 22 |
DOIs | |
Publication status | Published - 8 Jun 2020 |
Keywords
- Carbon dioxide
- Hydration
- Ionic liquid
- Silver catalysis
- α-Hydroxy ketones
ASJC Scopus subject areas
- Chemistry(all)
- Environmental Chemistry
- Chemical Engineering(all)
- Renewable Energy, Sustainability and the Environment