Copper-mediated isotopic exchange between [125I]iodide and bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate in aqueous media

E. Shchukin, A. Orlova, M. Korsakov, S. Sjöberg, V. Tolmachev

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Derivatives of dodecahydro-closo-dodecaborate(2-) anion were proposed as boron-rich compounds for boron-neutron capture therapy (BNCT) of malignant tumours. Labeling of such tumour-targeting compounds with radioisotopes would facilitate the investigation of their pharmacokinetics and help to optimize patient treatment protocols. Earlier, we reported the feasibility of labeling of closo-dodecaborate(2-) by isotopic exchange in molten acetamide. In this study, the feasibility of low-temperature isotopic exchange in the system [ 125I]iodide - bis(triethylammonium) undecahydro-12-iodo-closo- dodecaborate was investigated. Our attempts to perform the exchange in solvents such as methylene chloride, acetone and acetonitrile in the presence of phase-transfer catalysts were unsuccessful. However, copper mediated exchange in aqueous media was possible. Isotopic exchange of triethylammonium undecahydro-12-iodo-closo-dodecaborate provided a 90-95% labeling yield after heating for three and half hours at 100°C.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Issue number2
Publication statusPublished - 2004
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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