TY - JOUR
T1 - Copper-mediated isotopic exchange between [125I]iodide and bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate in aqueous media
AU - Shchukin, E.
AU - Orlova, A.
AU - Korsakov, M.
AU - Sjöberg, S.
AU - Tolmachev, V.
N1 - Funding Information:
This work was supported by grants from Swedish Cancer Society, Swedish Royal Academy of Sciences and INTAS. Authors thank Ms. Ylva ALMQUIST for a linguistic checking of the manuscript.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2004
Y1 - 2004
N2 - Derivatives of dodecahydro-closo-dodecaborate(2-) anion were proposed as boron-rich compounds for boron-neutron capture therapy (BNCT) of malignant tumours. Labeling of such tumour-targeting compounds with radioisotopes would facilitate the investigation of their pharmacokinetics and help to optimize patient treatment protocols. Earlier, we reported the feasibility of labeling of closo-dodecaborate(2-) by isotopic exchange in molten acetamide. In this study, the feasibility of low-temperature isotopic exchange in the system [ 125I]iodide - bis(triethylammonium) undecahydro-12-iodo-closo- dodecaborate was investigated. Our attempts to perform the exchange in solvents such as methylene chloride, acetone and acetonitrile in the presence of phase-transfer catalysts were unsuccessful. However, copper mediated exchange in aqueous media was possible. Isotopic exchange of triethylammonium undecahydro-12-iodo-closo-dodecaborate provided a 90-95% labeling yield after heating for three and half hours at 100°C.
AB - Derivatives of dodecahydro-closo-dodecaborate(2-) anion were proposed as boron-rich compounds for boron-neutron capture therapy (BNCT) of malignant tumours. Labeling of such tumour-targeting compounds with radioisotopes would facilitate the investigation of their pharmacokinetics and help to optimize patient treatment protocols. Earlier, we reported the feasibility of labeling of closo-dodecaborate(2-) by isotopic exchange in molten acetamide. In this study, the feasibility of low-temperature isotopic exchange in the system [ 125I]iodide - bis(triethylammonium) undecahydro-12-iodo-closo- dodecaborate was investigated. Our attempts to perform the exchange in solvents such as methylene chloride, acetone and acetonitrile in the presence of phase-transfer catalysts were unsuccessful. However, copper mediated exchange in aqueous media was possible. Isotopic exchange of triethylammonium undecahydro-12-iodo-closo-dodecaborate provided a 90-95% labeling yield after heating for three and half hours at 100°C.
UR - http://www.scopus.com/inward/record.url?scp=3543109069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3543109069&partnerID=8YFLogxK
U2 - 10.1023/B:JRNC.0000027099.63853.cc
DO - 10.1023/B:JRNC.0000027099.63853.cc
M3 - Article
AN - SCOPUS:3543109069
VL - 260
SP - 295
EP - 299
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
SN - 0236-5731
IS - 2
ER -