Copper-catalyzed synthesis of N-sulfonyl-1,2,3-triazoles: Controlling selectivity

Eun Jeong Yoo, Mårten Ahlquist, Seok Hwan Kim, Imhyuck Bae, Valery V. Fokin, K. Barry Sharpless, Sukbok Chang

Research output: Contribution to journalArticlepeer-review

259 Citations (Scopus)


(Chemical Equation Presented) 4-Substituted 1-(N-sulfonyl)-1,2,3-triazoles are selectively obtained by using the Cu-catalyzed azide-alkyne cycloaddition reaction with sulfonyl azides. Performing the reaction at 0°C in chloroform in the presence of 2,6-lutidine and Cul as the catalyst effectively prevents the ketenimine pathway and provides convenient access to N-sulfonyltriazoles in good to excellent yields.

Original languageEnglish
Pages (from-to)1730-1733
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number10
Publication statusPublished - 2007
Externally publishedYes


  • Alkynes
  • Copper
  • Cycloaddition
  • Sulfonyl azides
  • Sulfonyltriazoles

ASJC Scopus subject areas

  • Chemistry(all)

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