Copper-catalyzed reaction cascade: Direct conversion of alkynes into N-sulfonylazetidin-2-imines

Abstract

(Chemical Equation Presented) Selective conversion, take three: Densely functionalized azetidine derivatives are formed in an experimentally simple three-component catalytic procedure through the highly selective reaction of readily available terminal alkynes under mild conditions (see scheme). The azetidinimine products are remarkably stable to a wide range of reaction conditions and readily undergo further functionalization.

Original language	English
Pages (from-to)	3157-3161
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	19
DOIs	https://doi.org/10.1002/anie.200503936
Publication status	Published - 5 May 2006
Externally published	Yes

Keywords

Alkynes
Azides
Cycloaddition
Homogeneous catalysis
Small ring systems

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1002/anie.200503936

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Whiting, M., & Fokin, V. V. (2006). Copper-catalyzed reaction cascade: Direct conversion of alkynes into N-sulfonylazetidin-2-imines. Angewandte Chemie - International Edition, 45(19), 3157-3161. https://doi.org/10.1002/anie.200503936

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abstract = "(Chemical Equation Presented) Selective conversion, take three: Densely functionalized azetidine derivatives are formed in an experimentally simple three-component catalytic procedure through the highly selective reaction of readily available terminal alkynes under mild conditions (see scheme). The azetidinimine products are remarkably stable to a wide range of reaction conditions and readily undergo further functionalization.",

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